Gen Surg Cases · surgical-critical-care
Post-laparotomy shock with AKI, refeeding risk and hyperglycaemia — feed, bridge, restrict and cap
Fellowship clinical-management station on surgical ICU nutrition: trophic enteral dosing, EPaNIC parenteral timing, NUTRIREA-2 shock-gut bridging, EFFORT protein restraint in AKI, refeeding restriction, NICE-SUGAR glucose caps, prokinetics and tube routing.
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Resuscitation and perfusion first — nutrition serves recovery, never precedes it. He is in vasopressor-dependent shock with a tenuous post-laparotomy abdomen: complete resuscitation, confirm source control, and read the abdomen (distension, drain output, stool, flatus, lactate trajectory) before any feeding rate is chosen. Shock owns pressors and perfusion targets — this station owns what follows.[11]
Start enteral trophic, withhold PN, bridge only if shock escalates. Begin low-volume EN now and advance on tolerance and perfusion: EDEN and PermiT both tied full against moderate delivery on death with less intolerance on the moderate side.[1][3] Do not top up with PN on day 2: EPaNIC favours day-8 initiation with faster recovery and fewer infections.[6] If noradrenaline escalates with rising lactate and an unpassed abdomen, stop advancing EN and bridge with PN — NUTRIREA-2 showed forced isocaloric EN in shock raised bowel ischaemia without survival gain.[11]
Dose protein for the AKI, restrict for the phosphate fall. Oliguric kidney injury means usual-dose protein, not 2.2 g per kg per day: EFFORT harm concentrated in AKI with RR 1.4 for 60-day death.[13] Eight starved days plus a post-feed phosphate fall means temporary macronutrient restriction with electrolyte repletion: the refeeding trial improved day-60 survival to 91 percent, and relative phosphate falls mark early-PN harm.[21][9]
Cap glucose, prokinet intolerance, route for delivery. Hold glucose at 180 or less with frequent measurement — intensive 81-to-108 targeting raised death with thirteen-fold severe hypoglycaemia.[25] Treat high residuals with prokinetics (moderate-certainty intolerance reduction) and consider postpyloric placement for delivery shortfalls — never as pneumonia prevention, which it is not.[29][27]
Close with disposition and honesty. Daily intensivist, surgical, dietetic and pharmacy review of perfusion, tolerance, phosphate and glucose until stable ward feeding resumes. Name the gaps: no verified calorie formula, no adult residual cutoff, and guideline recommendations mostly on moderate evidence or expert opinion — individualise and document why.[31]
References11ShowHide
- [11]Reignier J, Boisramé-Helms J, Brisard L, et al. Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2). Lancet, 2018.PMID 29128300
- [1]Rice TW, Wheeler AP, Thompson BT, et al. Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial. JAMA, 2012.PMID 22307571
- [3]Arabi YM, Aldawood AS, Haddad SH, et al. Permissive Underfeeding or Standard Enteral Feeding in Critically Ill Adults. N Engl J Med, 2015.PMID 25992505
- [6]Casaer MP, Mesotten D, Hermans G, et al. Early versus late parenteral nutrition in critically ill adults. N Engl J Med, 2011.PMID 21714640
- [13]Heyland DK, Patel J, Compher C, et al. The effect of higher protein dosing in critically ill patients with high nutritional risk (EFFORT Protein): an international, multicentre, pragmatic, registry-based randomised trial. Lancet, 2023.PMID 36708732
- [21]Doig GS, Simpson F, Heighes PT, et al. Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlled trial. Lancet Respir Med, 2015.PMID 26597128
- [9]Lauwers C, Langouche L, Wouters PJ, et al. Early phosphate changes as potential indicator of unreadiness for artificial feeding: a secondary analysis of the EPaNIC RCT. Crit Care, 2025.PMID 39875953
- [25]Finfer S, Chittock DR, Su SY, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med, 2009.PMID 19318384
- [29]Lewis K, Alqahtani Z, Mcintyre L, et al. The efficacy and safety of prokinetic agents in critically ill patients receiving enteral nutrition: a systematic review and meta-analysis of randomized trials. Crit Care, 2016.PMID 27527069
- [27]Zhang Z, Xu X, Ding J, et al. Comparison of postpyloric tube feeding and gastric tube feeding in intensive care unit patients: a meta-analysis. Nutr Clin Pract, 2013.PMID 23614960
- [31]Reignier J, Gaillard-Le Roux B, Dequin PF, et al. Expert consensus‑based clinical practice guidelines for nutritional support in the intensive care unit: the French Intensive Care Society (SRLF) and the French-Speaking Group of Pediatric Emergency Physicians and Intensivists (GFRUP). Ann Intensive Care, 2025.PMID 40665004