GP CCE Cases · emergency-medicine
Anaphylaxis in the surgery — CCE clinical encounter
CCE-style clinical encounter: a 22-year-old develops a systemic reaction after an intramuscular antibiotic in the treatment room. The candidate must recognise anaphylaxis, give adrenaline correctly, sequence adjuncts, and close with a discharge package that survives the next reaction.
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Target exams
RACGP CCEFRACGP oralsCFPC SOOs
Prompt
A 22-year-old university student received intramuscular ceftriaxone in your treatment room for pelvic inflammatory disease. Ten minutes later she reports feeling 'hot and strange', her voice sounds hoarse, she has flushed skin with spreading weals, and she is coughing. Her observations: pulse 118, blood pressure 86/50, respiratory rate 26, oxygen saturation 93% on room air.
Objectives
- Recognise anaphylaxis clinically — rapid onset after a likely allergen with mucocutaneous, respiratory and cardiovascular involvement. [4]
- Deliver first-line treatment without delay: intramuscular adrenaline into the mid-anterolateral thigh at the correct dose, repeated as needed. [1] [24]
- Sequence adjuncts correctly — positioning, oxygen, intravenous fluids, bronchodilator — and reject the intravenous bolus shortcut outside monitored care. [4] [5]
- Order timed tryptase sampling without letting it delay treatment. [36] [15]
- Construct the discharge package: observation tier, two auto-injectors, demonstrated technique, written plan, specialist referral. [36]
References11ShowHide
- [1]Cardona V, Ansotegui IJ, Ebisawa M et al. World allergy organization anaphylaxis guidance 2020. The World Allergy Organization journal, 2020.PMID 33204386
- [4]Simons FE, Ardusso LR, Bilò MB et al. International consensus on (ICON) anaphylaxis. The World Allergy Organization journal, 2014.PMID 24920969
- [5]Campbell RL, Bellolio MF, Knutson BD et al. Epinephrine in anaphylaxis: higher risk of cardiovascular complications and overdose after administration of intravenous bolus epinephrine compared with intramuscular epinephrine. The Journal of allergy and clinical immunology. In practice, 2015.PMID 25577622
- [6]Lee S, Bellolio MF, Hess EP et al. Time of Onset and Predictors of Biphasic Anaphylactic Reactions: A Systematic Review and Meta-analysis. The Journal of allergy and clinical immunology. In practice, 2015.PMID 25680923
- [11]Choo KJ, Simons FE, Sheikh A Glucocorticoids for the treatment of anaphylaxis. Evidence-based child health, 2013.PMID 23877942
- [13]Delli Colli L, Al Ali A, Gabrielli S et al. Managing anaphylaxis: Epinephrine, antihistamines, and corticosteroids: More than 10 years of Cross-Canada Anaphylaxis REgistry data. Annals of allergy, asthma & immunology, 2023.PMID 37689113
- [15]Vitte J, Sabato V, Tacquard C et al. Use and Interpretation of Acute and Baseline Tryptase in Perioperative Hypersensitivity and Anaphylaxis. The Journal of allergy and clinical immunology. In practice, 2021.PMID 33746087
- [24]Patel N, Isaacs E, Duca B et al. Optimal dose of adrenaline auto-injector for children and young people at risk of anaphylaxis: A phase IV randomized controlled crossover study. Allergy, 2023.PMID 36794963
- [29]Galvan-Blasco P, Pereira-Gonzalez J, Cardona V Update on refractory anaphylaxis. Current opinion in allergy and clinical immunology, 2025.PMID 40747971
- [33]Kadivec S, Košnik M The Ability to Use Epinephrine Autoinjector in Patients Who Receive Prescription Immediately after Anaphylaxis. International archives of allergy and immunology, 2021.PMID 33486490
- [36]Dzingina M, Stegenga H, Heath M et al. Assessment and referral after emergency treatment of a suspected anaphylactic episode: summary of NICE guidance. BMJ, 2011.PMID 22171344