EM · Raised intracranial pressure
Raised intracranial pressure
Also known as Intracranial hypertension · ICP · Cerebral herniation syndrome · Intracranial hypertension syndrome
Raised intracranial pressure is the syndrome of the cranial contents exceeding the compensatory reserve of the rigid skull — the Monro-Kellie doctrine and the compliance curve, the cerebral perfusion pressure equation (CPP = MAP minus ICP), the Cushing triad as a late pre-terminal sign, the herniation syndromes (uncal, central, tonsillar), the emergency management ladder (head elevation, osmotherapy with mannitol 0.5 to 1 g per kg or hypertonic saline (3 per cent, or 23.4 per cent 30 to 60 mL), transient hyperventilation to PaCO2 35, neurosurgery), the LP-before-CT contraindication, and the no-steroids-in-trauma rule. ACEM-primary, globally tagged.
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8 MCQs with explanations
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Meet the patient
A 19-year-old is brought in after a pub assault, briefly knocked out, then "fine" and talking for two hours — the nurse now calls you because he has gone drowsy. The right pupil is 6 mm and fixed, the left arm will not move, and the obs flash up 174/92 with a heart rate of 52 and an irregular eight breaths a minute.[3]
That is the whole topic in one trolley: the lucid interval of an expanding extradural, the ipsilateral fixed pupil of uncal herniation, and the Cushing triad telling you the brainstem is ischaemic. Hold this patient and every paragraph below slots into place — the single question is whether you osmose and call the surgeon before the CT, not after.[3]
You have read the opening of this topic. The complete unit — every section and its primary-source references — is part of the Emergency Medicine fellowship atlas.
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- [1]Carney N, Totten AM, O'Reilly C, et al. Guidelines for the Management of Severe Traumatic Brain Injury, Fourth Edition. Neurosurgery, 2017.PMID 27654000
- [2]Godoy DA, Seifi A, Garza D, Lubillo-Montenegro S, Murillo-Cabezas F. Hyperventilation Therapy for Control of Posttraumatic Intracranial Hypertension. Frontiers in Neurology, 2017.PMID 28769857
- [3]Ramesh Kumar R. Raised intracranial pressure (ICP): management in emergency department. Indian Journal of Pediatrics, 2012.PMID 22218806
- [4]Roberts I, Yates D, Sandercock P, et al. Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial. Lancet, 2004.PMID 15474134
- [5]Hutchinson PJ, Kolias AG, Timofeev IS, et al. Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension. New England Journal of Medicine, 2016.PMID 27602507
- [6]Muizelaar JP, Marmarou A, Ward JD, et al. Adverse effects of prolonged hyperventilation in patients with severe traumatic head injury: a randomized clinical trial. Journal of Neurosurgery, 1991.PMID 1919695
- [7]Cooper DJ, Rosenfeld JV, Murray L, et al. Decompressive craniectomy in diffuse traumatic brain injury. New England Journal of Medicine, 2011.PMID 21434843
- [8]Hofmeijer J, Kappelle LJ, Algra A, Amelink GJ, van Gijn J, van der Worp HB. Surgical decompression for space-occupying cerebral infarction (the Hemicraniectomy After Middle Cerebral Artery infarction with Life-threatening Edema Trial [HAMLET]): a multicentre, open, randomised trial. Lancet Neurology, 2009.PMID 19269254
- [9]Chesnut RM, Temkin N, Carney N, et al. A trial of intracranial-pressure monitoring in traumatic brain injury. New England Journal of Medicine, 2012.PMID 23234472
- [10]Hawryluk GWJ, Rubiano AM, Totten AM, et al. Guidelines for the Management of Severe Traumatic Brain Injury: 2020 Update of the Decompressive Craniectomy Recommendations. Neurosurgery, 2020.PMID 32761068
- [11]Chesnut RM, Marshall LF, Klauber MR, et al. The role of secondary brain injury in determining outcome from severe head injury. Journal of Trauma, 1993.PMID 8459458
- [12]Kim H. Anesthetic management of the traumatic brain injury patients undergoing non-neurosurgery. Anesthesia and Pain Medicine, 2023.PMID 37183278
- [13]Vahedi K, Hofmeijer J, Juettler E, et al. Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials. Lancet Neurology, 2007.PMID 17303527
- [14]Zeiler FA, Teitelbaum J, West M, Gillman LM. The ketamine effect on ICP in traumatic brain injury. Neurocritical Care, 2014.PMID 24515638
- [15]Bullock MR, Chesnut R, Ghajar J, et al. Surgical management of acute subdural hematomas. Neurosurgery, 2006.PMID 16710968
- [16]Ryken TC, McDermott M, Robinson PD, et al. The role of steroids in the management of brain metastases: a systematic review and evidence-based clinical practice guideline. Journal of Neuro-Oncology, 2010.PMID 19957014
- [17]Koenig MA, Bryan M, Lewin JL 3rd, Mirski MA, Geocadin RG, Stevens RD. Reversal of transtentorial herniation with hypertonic saline. Neurology, 2008.PMID 18272864
- [18]Avery RA. Interpretation of lumbar puncture opening pressure measurements in children. Journal of Neuro-Ophthalmology, 2014.PMID 25133882
- [19]Edge JA, Hawkins MM, Winter DL, Dunger DB. The risk and outcome of cerebral oedema developing during diabetic ketoacidosis. Archives of Disease in Childhood, 2001.PMID 11420189
- [20]Fink ME. Osmotherapy for intracranial hypertension: mannitol versus hypertonic saline. Continuum, 2012.PMID 22810253
- [21]Edwards P, Arango M, Balica L, et al. Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury-outcomes at 6 months. Lancet, 2005.PMID 15936423