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Q1: Definition and classification (2 min)
Define epidermolysis bullosa in one sentence. Name the four major groups and state the level of skin cleavage in each.
Q2: Pathophysiology (2 min)
Explain the basement-membrane-zone proteins and genes involved in EB simplex, junctional EB, and dystrophic EB. Why is dystrophic EB associated with scarring and milia?
Q3: Clinical presentation (3 min)
A neonate presents with widespread blistering, periorificial granulation tissue, and hoarseness. Which EB subtype is most likely, and what are the immediate life-threatening concerns? How would you distinguish this from staphylococcal scalded skin syndrome?
Q4: Investigations and diagnosis (2 min)
What is the diagnostic gold standard for determining the level of split in EB? Name the key monoclonal antibodies used in immunofluorescence mapping. What is the role of genetic testing?
Q5: Management and prognosis (3 min)
Outline the four pillars of EB wound care. Discuss the role of multidisciplinary care, nutritional support, and the newer gene therapy option for dystrophic EB. What is the cumulative risk of squamous cell carcinoma in severe recessive dystrophic EB by age 55?