Derm SAQs ·
BRAF Mutations in Melanoma: Biological Aspects, Therapeutic Implications, and Circulating Biomarkers. — SAQ
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A patient presents with features suggestive of braf mutations in melanoma: biological aspects, therapeutic implications, and circulating biomarkers.. Cutaneous melanoma is a malignant tumour of melanocytes driven predominantly by UV-induced oncogenic mutations in the MAPK and PI3K pathways (BRAF V600E ~50%, NRAS, NF1), clinically presenting as a ne...
Questions
a) What is the most likely diagnosis and what clinical features support it? (2 marks)
b) What investigations would you arrange to confirm the diagnosis? (3 marks)
c) Outline your management plan for this patient. (3 marks)
d) What are the key complications and prognostic factors? (2 marks)