Anaes · Critical incidents
Aspiration and regurgitation
Also known as Pulmonary aspiration · Mendelson syndrome · Aspiration pneumonitis · Rapid sequence induction · RSI · Cricoid pressure · Modified RSI
Exam-exhaustive pulmonary aspiration: risk factors including GLP-1 agonists, Mendelson chemical pneumonitis vs pneumonia, classic vs modified RSI, cricoid evidence (Birenbaum), management if aspiration occurs, and when to cancel vs continue surgery for ANZCA Final and equivalents.
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Red flags
- Mendelson pneumonitis is chemical injury — suction, oxygenate, protective ventilation; no routine lavage, no prophylactic antibiotics, no steroids as standard care.
- Risk stack: non-fasted, obstruction/ileus, pregnancy, obesity, reflux, diabetes gastroparesis, opioids, GLP-1 agonists, depressed consciousness, emergency surgery.
- RSI protects the high-risk airway — preoxygenate, rapid induction + fast NMB, cricoid with release if it worsens the view (Birenbaum: no clear aspiration benefit).
- If gross aspiration occurs: head-down/lateral if feasible, suction before positive pressure when possible, secure ETT, then decide cancel vs continue on clinical severity.
- NAP4: aspiration remains a major anaesthetic airway harm — risk recognition and planned airway strategy prevent more cases than heroic recovery.
Meet the patient
A 68-year-old with small-bowel obstruction arrives for an emergency laparotomy, vomiting for two days. The induction dose goes in, and bilious fluid wells into the pharynx and spills past the cords before the cuff is inflated.[1]
The next thirty seconds matter most. Suction first, secure the airway, oxygenate gently — then decide: cancel or continue?[1]
References5ShowHide
- [1]Cook TM, Woodall N, Frerk C. Major complications of airway management in the UK: results of the Fourth National Audit Project of the Royal College of Anaesthetists and the Difficult Airway Society. Part 1: anaesthesia Br J Anaesth, 2011.PMID 21447488
- [2]Birenbaum A, Hajage D, Roche S, et al. Effect of Cricoid Pressure Compared With a Sham Procedure in the Rapid Sequence Induction of Anesthesia: The IRIS Randomized Clinical Trial JAMA Surg, 2019.PMID 30347104
- [3]Sorbello M, et al. Pharmacological approach to rapid sequence induction/intubation: a contemporary perspective Curr Opin Anaesthesiol, 2025.PMID 40493782
- [4]Davies A. AANA Journal Course-GLP-1 Receptor Agonists: What CRNAs Need to Know About Their Expanding Role AANA J, 2026.PMID 42213027
- [5]Mendelson CL. The aspiration of stomach contents into the lungs during obstetric anesthesia Am J Obstet Gynecol, 1946.PMID 20993766