Anaes Cases · TIVA & target-controlled infusion
Schnider LBM and obesity
Short case — Schnider LBM overestimate in obesity. Lean body mass formula breaks down at high BMI; overestimate leads to overdose. Adjust: use height-based LBM cap or Eleveld model.
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ANZCAFRCAABAEDAIC
Prompt
A 120 kg patient for elective surgery. TCI pump set with Schnider model using actual weight. Discuss the issue.
Presentation
A 120 kg man (BMI 38) for elective surgery. TCI pump set with Schnider model using actual weight 120 kg. Initial propofol target 5 mcg/mL effect-site. Discuss the issue.
[1]References1ShowHide
- [1]Keresztes M, et al. Target-Controlled Infusion for Caesarean Delivery Under General Anesthesia: From Conventional Pharmacokinetic Models to Physiologically Based Pharmacokinetic Modeling. Life, 2026.PMID 42195295