Overview
Skin Abscess
Quick Reference
Critical Alerts
- Incision and drainage (I&D) is primary treatment: Antibiotics alone are insufficient
- MRSA is common pathogen: Consider in purulent infections
- Antibiotics adjunct in select cases: Surrounding cellulitis, systemic illness, immunocompromise
- Rule out necrotizing fasciitis: Disproportionate pain, rapid spread, crepitus
- Packed wounds may need repacking: Follow-up in 24-48 hours
- Recurrent abscesses warrant MRSA decolonization consideration
Necrotizing Fasciitis Warning Signs
| Finding | Action |
|---|---|
| Severe pain out of proportion | Urgent surgical consult |
| Rapid spread | Imaging, surgery |
| Crepitus | CT, emergent surgery |
| Systemic toxicity | Resuscitate, broad IV antibiotics, surgery |
| Skin necrosis | Emergent surgery |
Emergency Treatments
| Intervention | Details |
|---|---|
| I&D | Primary treatment |
| Packing | For large cavities |
| TMP-SMX or Doxycycline | If adjunct antibiotics indicated |
| Clindamycin | Alternative |
Definition
Overview
A skin abscess is a localized collection of pus within the dermis and deeper skin tissues. It is most commonly caused by Staphylococcus aureus, including MRSA. Incision and drainage (I&D) is the primary treatment. Antibiotics are adjunctive in select cases. The key ED task is distinguishing simple abscess from complicated infection (cellulitis, necrotizing fasciitis).
Classification
By Size/Depth:
| Type | Description |
|---|---|
| Furuncle (boil) | Single hair follicle |
| Carbuncle | Cluster of furuncles, multiple drainage sites |
| Simple abscess | Single, localized collection |
Epidemiology
- Very common: ~3% of ED visits are skin/soft tissue infections
- Rising incidence: Community-acquired MRSA (CA-MRSA)
- Common sites: Buttocks, groin, axilla, extremities
Etiology
Pathogens:
| Organism | Notes |
|---|---|
| S. aureus | Most common; includes MRSA |
| Streptococcus | Less common |
| Polymicrobial | Perianal, groin abscesses |
| Gram-negatives | Immunocompromised, injection drug use |
Risk Factors:
| Factor | Notes |
|---|---|
| MRSA colonization | Prior CA-MRSA infection |
| Crowded settings | Close contact, shared equipment |
| Athletes | Skin trauma, shared towels |
| Injection drug use | Skin inoculation |
| Diabetes | Immunocompromise |
| Poor hygiene |
Pathophysiology
Mechanism
- Bacterial entry: Through break in skin (folliculitis, trauma, shaving)
- Local infection: Bacteria proliferate
- Inflammatory response: Neutrophils, localized swelling
- Abscess formation: Walled-off pus collection
- Fluctuance: Indicates liquid center
Clinical Presentation
Symptoms
| Finding | Description |
|---|---|
| Pain | Tender, throbbing |
| Swelling | Localized, may be extensive |
| Erythema | Surrounding redness |
| Warmth | Local heat |
| Fluctuance | Palpable fluid collection |
| Spontaneous drainage | May occur |
History
Key Questions:
Physical Examination
| Finding | Significance |
|---|---|
| Fluctuant mass | Abscess |
| Surrounding erythema | Cellulitis component |
| Induration | Inflammatory response |
| Lymphadenopathy | Spread |
| Fever, tachycardia | Systemic response |
| Crepitus | Necrotizing fasciitis |
Duration and progression
Common presentation.
Prior similar infections
Common presentation.
Diabetes or immunocompromise
Common presentation.
Injection drug use
Common presentation.
Recent skin trauma or procedure
Common presentation.
MRSA history
Common presentation.
Red Flags
Necrotizing Fasciitis
| Finding | Action |
|---|---|
| Pain out of proportion to appearance | Emergent surgery |
| Rapid spread | CT, surgery |
| Crepitus | CT, surgery |
| Skin necrosis, bullae | Surgery |
| Systemic toxicity | Resuscitation, IV antibiotics, surgery |
Complicated Abscess
| Finding | Consideration |
|---|---|
| Large size (> cm) | May need antibiotics |
| Multiple abscesses | MRSA; may need antibiotics |
| Surrounding cellulitis | Antibiotics indicated |
| Immunocompromised | Antibiotics, close follow-up |
| Location (face, hand, genitals) | Specialist referral |
Differential Diagnosis
Other Causes of Skin Swelling
| Diagnosis | Features |
|---|---|
| Cellulitis | Diffuse erythema, no fluctuance |
| Necrotizing fasciitis | Severe pain, rapid spread, crepitus |
| Infected cyst | History of prior cyst |
| Hidradenitis suppurativa | Chronic, recurrent, axillae/groin |
| Infected injection site | IVDU history |
Diagnostic Approach
Clinical Diagnosis
- Abscess is a clinical diagnosis
- Fluctuance is key finding
Ultrasound
Indications:
- Differentiating abscess from cellulitis
- Locating abscess for I&D
- Assessing size and depth
Findings:
- Hypoechoic fluid collection
- Posterior acoustic enhancement
Laboratory
| Test | Indication |
|---|---|
| Wound culture | Large/recurrent abscesses, MRSA concern |
| CBC | Systemic illness |
| Blood cultures | Sepsis, endocarditis concern (IVDU) |
Treatment
Principles
- I&D is primary treatment: Antibiotics alone insufficient
- Antibiotics are adjunctive: For select cases
- Wound care: Packing, dressing
- Follow-up: For wound check, repacking
Incision and Drainage
Technique:
- Prep and drape
- Local anesthesia (lidocaine; field block or infiltration)
- Incise over fluctuant area (stab incision or full incision)
- Express pus completely
- Break up loculations (hemostat or finger)
- Irrigate with saline
- Pack wound (if large cavity)
- Dress wound
Packing:
- Indicated for cavities >1 cm
- Iodoform or plain gauze
- Remove/replace in 24-48 hours
Antibiotics (When Indicated)
Indications:
| Indication | Notes |
|---|---|
| Surrounding cellulitis | > cm |
| Systemic symptoms (fever) | |
| Immunocompromised | Diabetes, HIV |
| Multiple abscesses | |
| High-risk location (face, hand) | |
| No improvement after I&D |
First-Line (MRSA Coverage):
| Agent | Dose | Duration |
|---|---|---|
| TMP-SMX DS | 1-2 tabs BID | 5-7 days |
| Doxycycline | 100 mg BID | 5-7 days |
| Clindamycin | 300-450 mg TID | 5-7 days |
For Strep Coverage (If Needed):
- Add amoxicillin or amoxicillin-clavulanate
Analgesia
| Agent | Dose |
|---|---|
| Acetaminophen | 650-1000 mg q6h |
| Ibuprofen | 400-600 mg q6h |
| Opioids (short-term) | If severe pain |
Disposition
Discharge Criteria
- Successful I&D
- No systemic illness
- Able to perform wound care or have follow-up for repacking
- Reliable follow-up
Admission Criteria
- Necrotizing fasciitis concern
- Extensive cellulitis
- Sepsis
- Failed outpatient I&D
- Immunocompromised with severe infection
- Facial abscess with concern for spread
Referral
| Indication | Referral |
|---|---|
| Perirectal/Perianal abscess | Surgery |
| Facial abscess near eyes/midface | ENT or surgery |
| Breast abscess | Surgery or OB |
| Pilonidal abscess | Surgery |
| Recurrent hidradenitis | Dermatology, surgery |
Follow-Up
| Situation | Follow-Up |
|---|---|
| Packed wound | 24-48 hours for repacking |
| Uncomplicated | PCP in 1-2 weeks |
| Recurrent | Consider MRSA decolonization |
Patient Education
Condition Explanation
- "You have a skin abscess, which is a pocket of pus under the skin."
- "The best treatment is to drain it, which we did."
- "You may need antibiotics to help prevent the infection from spreading."
Wound Care
- Keep dressing clean and dry
- Return for packing removal/change in 24-48 hours
- Warm compresses may help
- Take antibiotics as directed (if prescribed)
Prevention (MRSA)
- Don't share towels, razors, or personal items
- Keep cuts and scrapes clean and covered
- Wash hands frequently
- Consider bleach baths (1/4 cup bleach to full bathtub) if recurrent
Warning Signs to Return
- Fever
- Increasing redness or swelling
- Pain getting worse
- Red streaks spreading
- Not improving in 48 hours
Special Populations
Diabetes
- Higher infection risk
- Consider antibiotics even for simple abscess
- Close follow-up
Immunocompromised
- Broader antibiotic coverage
- Lower threshold for admission
- Consider atypical pathogens
Injection Drug Users
- Consider endocarditis if bacteremia
- Blood cultures if febrile
- Screen for HIV, hepatitis
Recurrent Abscesses
- Consider MRSA decolonization
- Mupirocin nasal ointment × 5 days
- Bleach baths
- Chlorhexidine washes
Quality Metrics
Performance Indicators
| Metric | Target | Rationale |
|---|---|---|
| I&D performed for abscess | 100% | Primary treatment |
| Wound culture for recurrent/large | >0% | Guide therapy |
| Antibiotic only when indicated | >0% | Stewardship |
| Follow-up arranged for packed wounds | 100% | Wound care |
Documentation Requirements
- Size of abscess
- Amount of purulent drainage
- Presence of cellulitis
- Wound packing
- Antibiotic prescribed (if any)
- Follow-up plan
Key Clinical Pearls
Diagnostic Pearls
- Fluctuance = Abscess: Needs I&D
- Ultrasound if uncertain: Differentiates abscess from cellulitis
- Pain out of proportion = Necrotizing fasciitis: Emergency
- Recurrent abscesses suggest MRSA colonization
- Perirectal abscess needs surgical evaluation
Treatment Pearls
- I&D is primary treatment: Antibiotics alone don't work
- Pack large cavities: Prevents premature closure
- TMP-SMX or doxycycline for MRSA coverage: If antibiotics needed
- Antibiotics NOT needed for simple, uncomplicated abscess
- Warm compresses promote drainage
Disposition Pearls
- Most can be discharged: After I&D
- Follow-up for packing removal: 24-48 hours
- Admit for nec fasc, sepsis, or extensive infection
- MRSA decolonization for recurrent cases
References
- Stevens DL, et al. Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections. Clin Infect Dis. 2014;59(2):e10-e52.
- Daum RS. Skin and Soft-Tissue Infections Caused by Methicillin-Resistant Staphylococcus aureus. N Engl J Med. 2007;357(4):380-390.
- Talan DA, et al. Trimethoprim-Sulfamethoxazole versus Placebo for Uncomplicated Skin Abscess. N Engl J Med. 2016;374(9):823-832.
- Singer AJ, et al. Comparison of wound packing to no wound packing following incision and drainage of superficial skin abscesses. Ann Emerg Med. 2016;66(2):130-136.
- Taira BR, et al. Prospective randomized trial on packing versus no packing after drainage of subcutaneous cutaneous abscess. J Emerg Med. 2018;55(6):755-761.
- IDSA Guidelines. Skin and soft tissue infections. 2014.
- CDC. MRSA in Healthcare Settings. 2024.
- UpToDate. Skin abscesses, furuncles, and carbuncles. 2024.