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Renal Colic

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Overview

Renal Colic

Quick Reference

Critical Alerts

  • Infected obstructing stone (pyonephrosis) is a urological emergency requiring immediate decompression
  • Solitary kidney obstruction risks complete renal failure
  • Bilateral obstructing stones rare but can cause acute kidney injury
  • Stone size >10mm unlikely to pass spontaneously - early urology referral
  • NSAIDs are first-line analgesia - more effective than opioids for renal colic

Key Diagnostics

  • Non-contrast CT (NCCT) abdomen/pelvis is gold standard
  • Urinalysis (hematuria in 80-90%)
  • BUN/Creatinine (renal function, especially if bilateral or single kidney)
  • CBC if infection suspected
  • Urine culture if fever or UTI symptoms

Emergency Treatments

  • Analgesia: Ketorolac 15-30mg IV/IM + Acetaminophen 1g IV
  • Opioids: Morphine 0.1mg/kg IV for severe pain or NSAID contraindication
  • Antiemetics: Ondansetron 4-8mg IV
  • IV fluids: Judicious - aggressive hydration not proven beneficial
  • Medical expulsive therapy: Tamsulosin 0.4mg daily for stones 5-10mm

Definition

Renal colic refers to the acute pain caused by urinary tract stones (urolithiasis) obstructing the collecting system. The term "colic" describes the intermittent, cramping nature of the pain, though in reality, many patients experience constant severe pain with fluctuating intensity.

Stone Types

TypeFrequencyAppearance on CTRisk Factors
Calcium oxalate60-80%RadiodenseHypercalciuria, hyperoxaluria, low citrate
Calcium phosphate10-20%RadiodenseRenal tubular acidosis, hyperparathyroidism
Uric acid5-10%Radiolucent (may not see on plain film)Gout, high purine diet, acidic urine
Struvite5-10%Moderate densityUTI with urease-producing organisms
Cystine1-3%Moderate densityCystinuria (hereditary)

Epidemiology

  • Lifetime prevalence: 5-15%
  • Recurrence rate: 50% within 5-10 years
  • Peak incidence: Ages 20-60 years
  • Sex ratio: Male > Female (2:1), gap narrowing
  • Seasonal variation: More common in summer (dehydration)

Stone Location Terminology

TermLocation
NephrolithiasisKidney stone (any location)
UreterolithiasisStone in ureter
Proximal ureteralUpper 1/3 of ureter
Mid-ureteralMiddle 1/3
Distal ureteralLower 1/3, near bladder
Ureterovesical junction (UVJ)Most common impaction site

Pathophysiology

Mechanism of Stone Formation

Supersaturation Theory

  1. Urinary concentration of stone-forming substances exceeds solubility
  2. Crystal nucleation occurs
  3. Crystal aggregation and growth
  4. Stone retention in collecting system

Contributing Factors

  • Low urine volume (dehydration)
  • Elevated urinary calcium, oxalate, uric acid
  • Low urinary citrate (inhibitor)
  • Urinary pH extremes (acidic = uric acid; alkaline = calcium phosphate)
  • Urinary stasis

Mechanism of Pain

Acute Obstruction Cascade

  1. Stone impacts at narrow points (UPJ, crossing iliac vessels, UVJ)
  2. Ureteral peristalsis increases (attempting to expel)
  3. Intraluminal pressure rises
  4. Renal capsule distension
  5. Prostaglandin release → pain + ureteral spasm
  6. Referred pain via T10-L1 dermatomes

Pain Distribution

Stone LocationPain Pattern
Renal pelvis/UPJFlank, costovertebral angle
Proximal ureterFlank radiating to abdomen
Mid-ureterLower abdomen, groin
Distal ureter/UVJGroin, testicle/labia, suprapubic

Natural History

Spontaneous Passage Rates

Stone SizePassage RateAverage Time
<5mm70-90%Days to 4 weeks
5-10mm20-50%2-4 weeks
>0mm<10%Rarely spontaneous

Clinical Presentation

Classic Presentation

Pain Characteristics

Associated Symptoms

SymptomFrequencyNotes
Nausea/vomiting60-80%From visceral nerve stimulation
Hematuria80-90%Microscopic or gross
Dysuria30-40%Especially distal stones
Urinary urgency/frequency20-30%Distal ureteral/UVJ stones
Testicular/labial painCommonReferred from distal ureter

Physical Examination

Vital Signs

Examination Findings

FindingSignificance
Costovertebral angle tendernessCommon, sensitive but not specific
Writhing, cannot stay stillClassic for renal colic
Guarding, reboundConsider alternative diagnosis
Abnormal genitourinary examConsider torsion, epididymitis, hernia

Atypical Presentations

Consider Alternative Diagnoses If:


Location
Flank, radiating to groin, testicle, or labia
Onset
Sudden, severe
Character
Colicky with constant severe background
Pattern
Waxing and waning with superimposed peaks
Movement
Writhing, unable to find comfortable position
Red Flags (Life-Threatening)

Critical Presentations

Red FlagConcernAction
Fever + obstructing stoneInfected hydronephrosis (pyonephrosis)Emergency urology, decompression
AnuriaBilateral obstruction or single kidneyEmergency imaging and urology
Rising creatinineAcute kidney injury from obstructionUrgent urology consultation
SepsisUrosepsisResuscitation, decompression
Intractable pain/vomitingUnable to manage outpatientAdmission consideration
Stone >0mmUnlikely to passUrology referral for intervention

Infected Obstructing Stone (Pyonephrosis)

Clinical Features

  • Flank pain + fever + rigors
  • May progress rapidly to septic shock
  • Urology emergency

Management

  • Blood cultures, IV antibiotics
  • Emergency decompression (ureteral stent or nephrostomy)
  • Do NOT attempt lithotripsy until sepsis controlled

Differential Diagnosis

By Symptom Pattern

Flank Pain

ConditionDistinguishing Features
Renal colicColicky, radiates to groin, hematuria
PyelonephritisFever, pyuria, constant pain
AAA/dissectionOlder, pulsatile mass, cardiovascular risk
MusculoskeletalPositional, reproducible with palpation
Herpes zosterDermatomal, vesicular rash

Lower Abdominal/Groin Pain

ConditionDistinguishing Features
AppendicitisRLQ, anorexia, peritoneal signs
Ovarian pathologyFemale, mid-cycle, adnexal tenderness
Ectopic pregnancyFemale, positive pregnancy test
Testicular torsionScrotal pain, abnormal lie
Strangulated herniaGroin mass, bowel obstruction signs

Key Mimics to Rule Out

Abdominal Aortic Aneurysm

  • Age >60, cardiovascular risk factors
  • May have pulsatile mass
  • Consider bedside ultrasound
  • Pain may radiate to back/flank

Ectopic Pregnancy

  • Always check pregnancy test in reproductive-age females
  • Shoulder tip pain if ruptured
  • May have hematuria

Diagnostic Approach

Laboratory Studies

TestPurposeFindings
UrinalysisHematuria, leukocytesRBCs in 80-90%; pyuria suggests infection
Urine cultureIf infection suspectedObtain before antibiotics
Pregnancy testExclude ectopicAll reproductive-age females
BMPRenal functionElevated if AKI or chronic kidney disease
CBCInfectionLeukocytosis with left shift

Urinalysis Interpretation

  • Hematuria absent in 10-20% of proven stones
  • Pyuria without bacteriuria common from inflammation
  • WBCs + bacteria + obstruction = emergency

Imaging

Non-Contrast CT Abdomen/Pelvis (Gold Standard)

AdvantageLimitation
Sensitivity/specificity >5%Radiation exposure
Identifies all stone typesCost
Shows stone size and locationMay miss small UVJ stones
Identifies alternative diagnoses

CT Findings

  • Direct visualization of stone
  • Hydronephrosis/hydroureter
  • Perinephric stranding
  • Rim sign around stone
  • Measurement of stone size

Ultrasound

AdvantageLimitation
No radiationCannot see all stones (especially ureteral)
Pregnancy safeOperator dependent
Shows hydronephrosisLess specific
Rapidly available

When to Use Ultrasound First

  • Pregnancy
  • Known recurrent stone former
  • Pediatric patients
  • Young patients with classic presentation

Plain Radiograph (KUB)

  • Limited sensitivity (50-60%)
  • Cannot detect uric acid or other radiolucent stones
  • Useful for follow-up of known calcium stones

Imaging Algorithm

Suspected Renal Colic
        ↓
Pregnancy test (if applicable)
        ↓
Classic presentation + hematuria?
        ↓
    [YES]                        [NO or UNCERTAIN]
        ↓                              ↓
  Low-dose NCCT              Standard NCCT or
  OR Point-of-care           consider alternative
  ultrasound first           diagnoses
        ↓
Stone confirmed?
        ↓
  [YES] → Size assessment → Management
        ↓
  [NO] → Consider alternative diagnoses
         Repeat testing if high suspicion

Treatment

Analgesia (First Priority)

First-Line: NSAIDs

Ketorolac 15-30mg IV/IM (max 30mg if &gt;65 or renal impairment)
OR
Ibuprofen 400-800mg PO
OR
Diclofenac 50-75mg IM

+ Acetaminophen 1g IV or PO (synergistic)

Evidence: NSAIDs are MORE effective than opioids for renal colic (Cochrane 2018)

Second-Line: Opioids

Morphine 0.1 mg/kg IV
OR
Fentanyl 1-2 mcg/kg IV

Indication:
- NSAID contraindication (renal impairment, GI bleed, allergy)
- Inadequate response to NSAIDs

Antiemetics

  • Ondansetron 4-8mg IV
  • Metoclopramide 10mg IV

IV Fluids

Traditional vs Evidence

  • Traditional teaching: "flush the stone"
  • Evidence: No benefit to aggressive IV hydration
  • May worsen pain if hydronephrosis present
  • Use fluids for dehydration/vomiting, not routinely

Medical Expulsive Therapy (MET)

Tamsulosin 0.4mg Daily

Indication: Distal ureteral stones 5-10mm
Duration: 4-6 weeks
NNT: ~4 (for stone passage)

Evidence: AUA Guidelines 2016 support MET for distal ureteral stones ≤10mm

Other Alpha-Blockers

  • Silodosin
  • Alfuzosin (less evidence)

Adjunctive Medications

  • Nifedipine: Limited evidence, not routinely recommended
  • Corticosteroids: No longer recommended

Indications for Urology Intervention

Emergent (Hours)

  • Infected obstructing stone
  • Complete anuria
  • Single kidney with obstruction
  • Bilateral obstructing stones

Urgent (24-48 Hours)

  • Stone >10mm (unlikely to pass)
  • High-grade obstruction with pain
  • Persistent obstruction + AKI
  • Social factors (travel, athlete, etc.)

Elective Referral

  • First-time stone for metabolic workup
  • Recurrent stones
  • Follow-up of conservative management

Surgical Options (Urology)

ModalityStone Size/LocationNotes
ESWL<20mm, renal or upper ureterOutpatient, non-invasive
UreteroscopyAny ureteral stoneHigher stone-free rates
PCNL>0mm renal stonesInvasive but effective
Ureteral stentTemporizing for obstructionBridge to definitive treatment
NephrostomyInfected obstructionEmergent decompression

Disposition

Discharge Criteria (Safe for Home)

  • Pain controlled with oral medications
  • Tolerating oral intake
  • Afebrile
  • No signs of infection
  • Stone <10mm with reasonable expectation of passage
  • Able to follow up with urology
  • Understands return precautions

Admission Criteria

  • Intractable pain or vomiting
  • Unable to tolerate oral intake
  • Signs of infection with obstruction
  • Acute kidney injury
  • Single functioning kidney with obstruction
  • Social factors (unable to access care if deteriorates)

Follow-up Recommendations

Discharge Instructions

  • Strain all urine for stone collection
  • High fluid intake (2-3L/day)
  • Pain medications as prescribed
  • Medical expulsive therapy if indicated

Follow-up Timeline

TimeframePurpose
24-72 hoursUrology if stone > 6-7mm or not passing
1-2 weeksRepeat imaging to assess passage
4-6 weeksStone should have passed; urology if not
3 monthsWith passed stone for metabolic workup

Return Precautions

Return immediately if:

  • Fever or chills
  • Unable to keep fluids down for >24 hours
  • Unable to urinate
  • Worsening pain despite medications
  • Blood in urine increasing significantly

Patient Education

Understanding Kidney Stones

  • Kidney stones form from minerals in urine
  • They cause pain as they travel through the urinary tract
  • Most small stones (under 5mm) pass on their own
  • Larger stones may require procedures

Stone Prevention

General Measures

  • Increase fluid intake (goal: 2.5L urine output/day)
  • Lemonade and orange juice increase citrate
  • Limit sodium intake
  • Moderate calcium intake (dietary calcium is protective!)
  • Limit animal protein

Stone-Specific Prevention

Stone TypePrevention
Calcium oxalateFluids, moderate oxalate, thiazides
Calcium phosphateTreat underlying condition
Uric acidFluids, decrease purines, alkalinize urine
StruvitePrevent/treat UTIs
CystineHigh fluids, alkalinize urine

Medication Instructions

  • Take tamsulosin (if prescribed) as directed
  • May cause dizziness - rise slowly from sitting/lying
  • Continue until stone passes or urology follow-up
  • NSAIDs can help with pain - take with food

Special Populations

Pregnancy

Considerations

  • Stone incidence same as non-pregnant
  • Most common in 2nd and 3rd trimester
  • Physiologic hydronephrosis can confuse diagnosis
  • Avoid CT if possible

Management

  • Ultrasound first-line imaging
  • MRI without contrast if needed
  • Analgesia: Acetaminophen, opioids (short-term)
  • Avoid NSAIDs (especially 3rd trimester)
  • Urology involvement for intervention

Pediatric Patients

  • Increasing incidence in children
  • Consider metabolic/genetic causes
  • Ultrasound first-line
  • Weight-based analgesia

Patients with Single Kidney

  • Any obstruction is potentially critical
  • Lower threshold for imaging
  • Urgent urology involvement
  • Close monitoring of renal function

Recurrent Stone Formers

  • May know their typical presentation
  • Low-dose CT or ultrasound appropriate
  • Metabolic workup essential
  • Prevention strategies crucial

Quality Metrics

Performance Indicators

MetricTarget
Time to analgesia<30 minutes
Appropriate imaging (NCCT)>0%
Pregnancy test before imaging (women)100%
Urology referral for stones >0mm100%
Strainer and follow-up instructions100%
MET prescribed for eligible stones>0%

Documentation Requirements

  • Pain scale documentation
  • Pregnancy test result (if applicable)
  • Stone size and location from imaging
  • Presence/absence of hydronephrosis
  • Renal function
  • Treatment provided
  • Disposition rationale
  • Clear follow-up plan

Key Clinical Pearls

Diagnostic Pearls

  1. Absence of hematuria doesn't exclude stones - 10-20% have none
  2. CT is gold standard but ultrasound first in pregnancy
  3. Consider AAA in older patients with first episode
  4. Pregnancy test every female of childbearing age
  5. Fever + obstruction = emergency

Treatment Pearls

  1. NSAIDs are superior to opioids for renal colic
  2. Don't push fluids - no benefit, may worsen pain
  3. Tamsulosin helps passage for distal stones 5-10mm
  4. Stone <5mm = high chance of passing
  5. Stone >10mm = needs intervention

Disposition Pearls

  1. Discharge most uncomplicated cases with urology follow-up
  2. Strain urine - stone analysis guides prevention
  3. Infected obstruction = admission and decompression
  4. Clear return precautions are essential
  5. Know when to call urology emergently

References
  1. Türk C, et al. EAU Guidelines on Diagnosis and Conservative Management of Urolithiasis. Eur Urol. 2016;69(3):468-474.
  2. Assimos D, et al. Surgical Management of Stones: AUA/Endourology Society Guideline. J Urol. 2016;196(4):1153-1160.
  3. Holdgate A, Pollock T. Nonsteroidal anti-inflammatory drugs (NSAIDs) versus opioids for acute renal colic. Cochrane Database Syst Rev. 2004.
  4. Worster A, Richards C. Fluids and diuretics for acute ureteric colic. Cochrane Database Syst Rev. 2005.
  5. Pickard R, et al. Medical expulsive therapy in adults with ureteric colic: a multicentre, randomised, placebo-controlled trial. Lancet. 2015;386(9991):341-349.
  6. Smith-Bindman R, et al. Ultrasonography versus computed tomography for suspected nephrolithiasis. N Engl J Med. 2014;371(12):1100-1110.

Version History
VersionDateChanges
1.02025-01-15Initial comprehensive version with 14-section template

At a Glance

EvidenceStandard
Last UpdatedRecently

Clinical Pearls

  • Female (2:1), gap narrowing

Guidelines

  • NICE Guidelines
  • BTS Guidelines
  • RCUK Guidelines