Placental Abruption
Critical Alerts
- Placental abruption is a leading cause of third-trimester bleeding and perinatal mortality
- Concealed abruption may present with minimal vaginal bleeding despite massive hemorrhage
- DIC occurs in 10-20% of severe abruptions
- Fetal mortality approaches 20-40% with significant abruptions
- Immediate delivery is indicated for maternal instability or fetal distress
Key Diagnostics
- Clinical diagnosis primarily - do not delay management for imaging
- Continuous fetal monitoring (CTG/EFM)
- CBC, coagulation panel (PT, PTT, fibrinogen, D-dimer)
- Type and crossmatch (anticipate massive transfusion)
- Ultrasound (may show retroplacental clot, but sensitivity only 25-50%)
Emergency Treatments
- Large-bore IV access (two 16-18G IVs)
- Fluid resuscitation: Crystalloid, then blood products
- Activate massive transfusion protocol if hemodynamically unstable
- Correct coagulopathy: FFP, cryoprecipitate (target fibrinogen >200 mg/dL)
- Immediate obstetric consultation: Delivery decision critical
- Emergency cesarean section if fetal distress or maternal instability
Placental abruption (abruptio placentae) is the premature separation of a normally implanted placenta from the uterine wall before delivery of the fetus. It is a significant cause of maternal and fetal morbidity and mortality and can occur at any time after 20 weeks of gestation.
Classification by Severity
| Grade | Clinical Features | Fetal Status | Management |
|---|---|---|---|
| Mild (Grade 1) | <500mL blood, minimal symptoms, hemodynamically stable | Normal FHR | Expectant/induction depending on gestational age |
| Moderate (Grade 2) | 500-1000mL blood, uterine tenderness, contractions | Fetal distress possible | Delivery usually indicated |
| Severe (Grade 3) | >000mL blood, hemodynamic instability, coagulopathy | Fetal demise common | Emergency cesarean section |
Epidemiology
- Incidence: 0.4-1% of pregnancies
- Recurrence risk: 5-15% (up to 25% with prior severe abruption)
- Mortality:
- Maternal: 1-2%
- Fetal: 20-40% (depending on severity)
Types of Abruption
Revealed (External)
- Blood dissects between membranes and uterus
- Exits through cervix
- Vaginal bleeding correlates better with blood loss
Concealed (Internal)
- Blood trapped behind placenta
- No or minimal vaginal bleeding
- Underestimates true blood loss (up to 2L hidden)
Mixed
- Combination of revealed and concealed
- Most common presentation
Mechanism of Separation
Initiating Events
- Rupture of maternal spiral arteries in decidua basalis
- Bleeding into decidua basalis
- Expanding hematoma separates placenta from uterine wall
- Compression and infarction of intervillous space
Consequences of Separation
- Reduced uteroplacental blood flow → fetal hypoxia
- Uterine irritability → painful contractions
- Progressive placental separation
- Potential fetal demise if >50% separation
Pathological Progression
Couvelaire Uterus
- Blood extravasates into myometrium
- Uterus appears purple/blue ("uteroplacental apoplexy")
- May impair uterine contraction postpartum (atony)
Coagulopathy Development
DIC Mechanism
- Thromboplastin release from damaged placenta
- Retroplacental clot consumes fibrinogen
- Activation of coagulation cascade
- Consumption of clotting factors
- Fibrinolysis
Risk of DIC
- 10-20% with severe abruption
- More common with fetal demise
- Fibrinogen <200 mg/dL associated with significant hemorrhage
Classic Presentation
Triad
- Vaginal bleeding (70-80%)
- Uterine tenderness/pain (66%)
- Fetal distress or demise (60%)
Symptoms
| Symptom | Frequency | Description |
|---|---|---|
| Vaginal bleeding | 70-80% | Dark red; amount may not reflect severity |
| Abdominal pain | 50-70% | Sudden, continuous, severe |
| Uterine tenderness | 66% | Diffuse, persistent |
| Back pain | Common | Posterior placenta location |
| Contractions | 20-35% | High frequency, may be tetanic |
| Decreased fetal movement | Variable | If fetal distress |
Physical Examination
Vital Signs
Abdominal Examination
Vaginal Examination
Patterns of Presentation
Chronic Abruption
Acute Abruption
Fetal Assessment
| Finding | Interpretation |
|---|---|
| Normal CTG | Reassuring; may still have mild abruption |
| Tachycardia | Early sign of fetal distress |
| Late decelerations | Uteroplacental insufficiency |
| Reduced variability | Fetal hypoxia |
| Bradycardia | Severe fetal compromise |
| Sinusoidal pattern | Severe fetal anemia |
| Absent FHR | Fetal demise |
Maternal Critical Findings
| Red Flag | Concern | Immediate Action |
|---|---|---|
| Hypotension (SBP <90) | Hemorrhagic shock | Massive transfusion, emergent delivery |
| DIC evidence | Coagulopathy | Correct with blood products |
| Tense, rigid uterus | Severe abruption | Emergent cesarean section |
| High-output urine | Acute tubular necrosis risk | Monitor closely |
| Signs of shock | Hypovolemia | Aggressive resuscitation |
| Increasing fundal height | Concealed hemorrhage | May be most dangerous presentation |
Fetal Critical Findings
| Red Flag | Concern | Action |
|---|---|---|
| Absent FHR | Fetal demise | Change management focus |
| Prolonged bradycardia | Severe distress | Emergent delivery |
| Sinusoidal pattern | Severe anemia | Emergent delivery |
| Repetitive late decels | Placental insufficiency | Expedite delivery |
High-Risk Features
Factors Predicting Poor Outcome
- Concealed retroplacental clot >60 mL
- Fibrinogen <150 mg/dL
- Class 3 hemorrhagic shock
- Fetal bradycardia or absent heart rate
- Gestational age <34 weeks
Other Causes of Third-Trimester Bleeding
| Condition | Key Distinguishing Features |
|---|---|
| Placenta previa | Painless bleeding, diagnosed on ultrasound |
| Vasa previa | Fetal hemorrhage, vessels over cervical os |
| Uterine rupture | Prior uterine surgery, sudden severe pain, fetal distress |
| Cervical pathology | Bleeding from cervix (polyps, cancer), cervical exam |
| Bloody show/labor | Associated with regular contractions, mucous |
| Trauma | History of injury, placental abruption secondary |
Comparison: Abruption vs Previa
| Feature | Placental Abruption | Placenta Previa |
|---|---|---|
| Pain | Severe, constant | Painless |
| Bleeding | Dark, may be concealed | Bright red, always external |
| Uterine tone | Increased, tender | Normal |
| Fetal status | Often distressed | Usually normal |
| Ultrasound | May not show clot | Diagnostic for previa |
| Coagulopathy | Common in severe | Rare |
Initial Assessment
Systematic Approach
- ABCs - maternal stabilization first
- Confirm fetal heart tones
- Assess vaginal bleeding (amount, character)
- Abdominal examination (uterine tenderness, tone)
- Avoid digital cervical exam until previa excluded
Laboratory Studies
| Test | Purpose | Critical Values |
|---|---|---|
| CBC | Anemia, platelet count | Hb drop, platelets <100k |
| Type & crossmatch | Blood products | Match 6+ units pRBCs |
| Fibrinogen | Coagulopathy | <200 mg/dL concerning |
| PT/PTT | Coagulation status | Prolonged suggests DIC |
| D-dimer | Fibrinolysis | Elevated in DIC |
| BMP | Renal function | Creatinine elevation |
| Kleihauer-Betke | Fetal-maternal hemorrhage | If Rh-negative mother |
Fetal Monitoring
Continuous Electronic Fetal Monitoring (EFM)
- Essential for all suspected abruptions
- Identify fetal distress early
- Guide timing of delivery
Interpretation
| Pattern | Concern Level |
|---|---|
| Reactive, normal variability | Reassuring |
| Tachycardia with reduced variability | Moderate |
| Repetitive late decelerations | Significant |
| Prolonged bradycardia | Critical |
| Sinusoidal pattern | Critical |
Imaging
Ultrasound
- Sensitivity only 25-50% for abruption
- May show:
- Retroplacental clot (hypoechoic)
- Elevated placental edge
- Subchorionic collection
- Normal ultrasound does NOT exclude abruption
- Useful to exclude placenta previa
Clinical Diagnosis
- Placental abruption is primarily a CLINICAL diagnosis
- Do not delay treatment for imaging
Initial Resuscitation
Maternal Stabilization
Step 1: Establish access
- Two large-bore IVs (16-18G)
- Consider central venous access if shock
- Blood samples for all labs including T&S
Step 2: Volume resuscitation
- Crystalloid 2L rapid infusion
- Activate massive transfusion protocol if:
- Hypotension despite 2L crystalloid
- Ongoing hemorrhage
- Coagulopathy
Step 3: Blood product replacement
- pRBCs: Target Hb >7 g/dL (>8 if ongoing bleeding)
- FFP: 1:1 ratio with pRBCs in massive transfusion
- Cryoprecipitate: If fibrinogen <200 mg/dL
- Platelets: If <50,000/μL with bleeding
Step 4: Correct coagulopathy
- Target fibrinogen >200 mg/dL
- Consider TXA if not yet delivered
Delivery Decision
Factors Influencing Mode and Timing
| Scenario | Management |
|---|---|
| Maternal hemodynamic instability | Emergent cesarean section |
| Fetal distress (non-reassuring CTG) | Emergent cesarean section |
| Fetal demise | Consider vaginal delivery if maternal stable |
| Stable mother + viable fetus + good CTG | May allow vaginal delivery |
| Preterm + mild abruption + stable | Consider expectant with close monitoring |
Cesarean Section Indications
- Maternal hemodynamic instability
- Fetal distress with viable fetus
- Progression despite resuscitation
- Unable to achieve rapid vaginal delivery
Vaginal Delivery Considerations
- Appropriate if:
- Maternal stability
- No fetal distress OR fetal demise
- Cervix favorable (dilated)
- Close monitoring available
- Avoid prolonged labor (risk of worsening)
- Continuous EFM essential
Intraoperative Management
Cesarean Section Considerations
- Anticipate increased blood loss (Couvelaire uterus)
- Blood products available in OR
- Uterotonic agents on standby
- Consider B-lynch sutures for atony
- Interventional radiology backup if available
- Prepare for possible hysterectomy
Management of Coagulopathy
DIC Treatment
Goal: Replace consumed factors faster than consumption
1. Cryoprecipitate: 10 units
- Contains fibrinogen, FVIII, vWF
- Target fibrinogen >200 mg/dL
2. FFP: 4-6 units
- All clotting factors
- 1:1 ratio with pRBCs in massive transfusion
3. Platelets: 1 apheresis unit
- If <50,000/μL with bleeding
- Target >50,000/μL
4. TXA (tranexamic acid): 1g IV
- Antifibrinolytic
- Give before delivery if possible
5. Monitor labs frequently
- Repeat fibrinogen, PT/PTT, platelets q1-2h
Rh Prophylaxis
- Kleihauer-Betke test to quantify fetal-maternal hemorrhage
- RhoGAM for Rh-negative mothers
- Standard dose: 300 mcg covers 30 mL fetal blood
- Larger doses if significant hemorrhage
ICU Admission Criteria
- Hemodynamic instability requiring ongoing resuscitation
- DIC or significant coagulopathy
- Postpartum hemorrhage with ongoing transfusion needs
- Multi-organ dysfunction
- Couvelaire uterus with atony risk
Labor and Delivery Admission
- All confirmed or suspected placental abruptions
- Continuous fetal and maternal monitoring
- Immediate OR availability
Post-Delivery Monitoring
Maternal
- Serial hematocrit
- Coagulation parameters
- Urine output
- Vital signs
- Fundal tone (risk of atony)
Neonatal
- Depends on gestational age and condition at delivery
- NICU involvement for preterm or distressed newborn
- Assess for anemia (may need transfusion)
Follow-up Recommendations
| Timeframe | Purpose |
|---|---|
| 24-48 hours postpartum | Ensure hemostasis, correct anemia |
| 2 weeks postpartum | Standard postpartum visit |
| Pre-conception counseling | Recurrence risk 5-15% |
| Next pregnancy | Early dating ultrasound, close monitoring |
Understanding Placental Abruption
- Placental abruption occurs when the placenta separates early
- It is a serious condition requiring immediate medical care
- Treatment focuses on stabilizing mother and baby
- Delivery may be needed urgently depending on severity
Signs of Complications
Return Immediately If:
- Heavy vaginal bleeding (soaking pad in 1 hour)
- Severe abdominal or back pain
- Decreased or absent fetal movement
- Dizziness, lightheadedness
- Fever or chills
Future Pregnancies
- Recurrence risk is 5-15% (higher with severe abruption)
- Close monitoring recommended in subsequent pregnancies
- Avoid risk factors (smoking, cocaine, uncontrolled hypertension)
- Regular prenatal care is essential
Risk Factor Modification
Modifiable Risk Factors
- Stop smoking
- Avoid cocaine and other recreational drugs
- Control blood pressure
- Maintain regular prenatal visits
Preterm Abruption
Considerations
- Balance fetal immaturity vs abruption severity
- Antenatal corticosteroids if 24-34 weeks and delivery not imminent
- Magnesium sulfate for neuroprotection if <32 weeks
- NICU consultation early
Expectant Management (Mild Abruption, Stable)
- Possible if:
- Hemodynamically stable
- Reassuring fetal status
- <34 weeks with no indication for immediate delivery
- Requires:
- Continuous monitoring initially
- Close observation
- Immediate OR availability
Hypertensive Disorders
- Preeclampsia/eclampsia increases abruption risk 3-5 fold
- Management of abruption may be complicated by:
- Existing coagulopathy (HELLP)
- Renal dysfunction
- Hepatic dysfunction
- Magnesium sulfate for seizure prophylaxis
Previous Cesarean Section
- Increased risk of placental abnormalities
- May have previa or accreta spectrum
- Higher complexity surgery if needed
Trauma in Pregnancy
- Abruption is major cause of fetal death after trauma
- Can occur with minor trauma
- Monitor 4-24 hours depending on severity
- Fetal monitoring for at least 4 hours
Performance Indicators
| Metric | Target |
|---|---|
| Time to fetal monitoring | <10 minutes |
| Blood products available within | <15 minutes |
| Fibrinogen checked | 100% of suspected abruptions |
| Time to cesarean (if indicated) | <30 minutes |
| Rh status documented | 100% |
Documentation Requirements
- Estimated blood loss (vaginal and concealed)
- Fetal heart rate and pattern
- Uterine examination (tone, tenderness)
- Coagulation status
- Transfusion products given
- Delivery decision rationale
- Neonatal and maternal outcomes
Diagnostic Pearls
- Clinical diagnosis - don't delay for imaging
- Concealed abruption may have minimal external bleeding
- Maternal tachycardia may be the first sign of significant hemorrhage
- Normal ultrasound does NOT exclude abruption
- Increasing fundal height suggests concealed hemorrhage
Management Pearls
- Fibrinogen is the most depleted factor - replace early
- 1:1:1 ratio of blood products in massive transfusion
- Early obstetric involvement is essential
- Fetal demise changes management - vaginal delivery usually possible
- Couvelaire uterus increases risk of postpartum atony
Disposition Pearls
- All suspected abruptions require admission
- Do not delay cesarean for coagulopathy - correct simultaneously
- Close postpartum monitoring - atony risk increased
- Counsel about recurrence before discharge
- Neonatal team involvement essential for preterm or distressed infant
- Oyelese Y, Ananth CV. Placental abruption. Obstet Gynecol. 2006;108(4):1005-1016.
- Downes KL, Grantz KL, Shenassa ED. Maternal, Labor, Delivery, and Perinatal Outcomes Associated with Placental Abruption: A Systematic Review. Am J Perinatol. 2017;34(10):935-957.
- Tikkanen M. Placental abruption: epidemiology, risk factors and consequences. Acta Obstet Gynecol Scand. 2011;90(2):140-149.
- American College of Obstetricians and Gynecologists. Practice Bulletin No. 183: Postpartum Hemorrhage. Obstet Gynecol. 2017.
- Ananth CV, Lavery JA, Vintzileos AM, et al. Severe placental abruption: clinical definition and associations with maternal complications. Am J Obstet Gynecol. 2016;214(2):272.e1-272.e9.
| Version | Date | Changes |
|---|---|---|
| 1.0 | 2025-01-15 | Initial comprehensive version with 14-section template |