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Placental Abruption

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Overview

Placental Abruption

Quick Reference

Critical Alerts

  • Placental abruption is a leading cause of third-trimester bleeding and perinatal mortality
  • Concealed abruption may present with minimal vaginal bleeding despite massive hemorrhage
  • DIC occurs in 10-20% of severe abruptions
  • Fetal mortality approaches 20-40% with significant abruptions
  • Immediate delivery is indicated for maternal instability or fetal distress

Key Diagnostics

  • Clinical diagnosis primarily - do not delay management for imaging
  • Continuous fetal monitoring (CTG/EFM)
  • CBC, coagulation panel (PT, PTT, fibrinogen, D-dimer)
  • Type and crossmatch (anticipate massive transfusion)
  • Ultrasound (may show retroplacental clot, but sensitivity only 25-50%)

Emergency Treatments

  • Large-bore IV access (two 16-18G IVs)
  • Fluid resuscitation: Crystalloid, then blood products
  • Activate massive transfusion protocol if hemodynamically unstable
  • Correct coagulopathy: FFP, cryoprecipitate (target fibrinogen >200 mg/dL)
  • Immediate obstetric consultation: Delivery decision critical
  • Emergency cesarean section if fetal distress or maternal instability

Definition

Placental abruption (abruptio placentae) is the premature separation of a normally implanted placenta from the uterine wall before delivery of the fetus. It is a significant cause of maternal and fetal morbidity and mortality and can occur at any time after 20 weeks of gestation.

Classification by Severity

GradeClinical FeaturesFetal StatusManagement
Mild (Grade 1)<500mL blood, minimal symptoms, hemodynamically stableNormal FHRExpectant/induction depending on gestational age
Moderate (Grade 2)500-1000mL blood, uterine tenderness, contractionsFetal distress possibleDelivery usually indicated
Severe (Grade 3)>000mL blood, hemodynamic instability, coagulopathyFetal demise commonEmergency cesarean section

Epidemiology

  • Incidence: 0.4-1% of pregnancies
  • Recurrence risk: 5-15% (up to 25% with prior severe abruption)
  • Mortality:
    • Maternal: 1-2%
    • Fetal: 20-40% (depending on severity)

Types of Abruption

Revealed (External)

  • Blood dissects between membranes and uterus
  • Exits through cervix
  • Vaginal bleeding correlates better with blood loss

Concealed (Internal)

  • Blood trapped behind placenta
  • No or minimal vaginal bleeding
  • Underestimates true blood loss (up to 2L hidden)

Mixed

  • Combination of revealed and concealed
  • Most common presentation

Pathophysiology

Mechanism of Separation

Initiating Events

  1. Rupture of maternal spiral arteries in decidua basalis
  2. Bleeding into decidua basalis
  3. Expanding hematoma separates placenta from uterine wall
  4. Compression and infarction of intervillous space

Consequences of Separation

  • Reduced uteroplacental blood flow → fetal hypoxia
  • Uterine irritability → painful contractions
  • Progressive placental separation
  • Potential fetal demise if >50% separation

Pathological Progression

Couvelaire Uterus

  • Blood extravasates into myometrium
  • Uterus appears purple/blue ("uteroplacental apoplexy")
  • May impair uterine contraction postpartum (atony)

Coagulopathy Development

DIC Mechanism

  1. Thromboplastin release from damaged placenta
  2. Retroplacental clot consumes fibrinogen
  3. Activation of coagulation cascade
  4. Consumption of clotting factors
  5. Fibrinolysis

Risk of DIC

  • 10-20% with severe abruption
  • More common with fetal demise
  • Fibrinogen <200 mg/dL associated with significant hemorrhage

Clinical Presentation

Classic Presentation

Triad

  1. Vaginal bleeding (70-80%)
  2. Uterine tenderness/pain (66%)
  3. Fetal distress or demise (60%)

Symptoms

SymptomFrequencyDescription
Vaginal bleeding70-80%Dark red; amount may not reflect severity
Abdominal pain50-70%Sudden, continuous, severe
Uterine tenderness66%Diffuse, persistent
Back painCommonPosterior placenta location
Contractions20-35%High frequency, may be tetanic
Decreased fetal movementVariableIf fetal distress

Physical Examination

Vital Signs

Abdominal Examination

Vaginal Examination

Patterns of Presentation

Chronic Abruption

Acute Abruption

Fetal Assessment

FindingInterpretation
Normal CTGReassuring; may still have mild abruption
TachycardiaEarly sign of fetal distress
Late decelerationsUteroplacental insufficiency
Reduced variabilityFetal hypoxia
BradycardiaSevere fetal compromise
Sinusoidal patternSevere fetal anemia
Absent FHRFetal demise

Tachycardia (may precede hypotension)
Common presentation.
Hypotension in severe cases
Common presentation.
Tachypnea
Common presentation.
Red Flags (Life-Threatening)

Maternal Critical Findings

Red FlagConcernImmediate Action
Hypotension (SBP <90)Hemorrhagic shockMassive transfusion, emergent delivery
DIC evidenceCoagulopathyCorrect with blood products
Tense, rigid uterusSevere abruptionEmergent cesarean section
High-output urineAcute tubular necrosis riskMonitor closely
Signs of shockHypovolemiaAggressive resuscitation
Increasing fundal heightConcealed hemorrhageMay be most dangerous presentation

Fetal Critical Findings

Red FlagConcernAction
Absent FHRFetal demiseChange management focus
Prolonged bradycardiaSevere distressEmergent delivery
Sinusoidal patternSevere anemiaEmergent delivery
Repetitive late decelsPlacental insufficiencyExpedite delivery

High-Risk Features

Factors Predicting Poor Outcome

  • Concealed retroplacental clot >60 mL
  • Fibrinogen <150 mg/dL
  • Class 3 hemorrhagic shock
  • Fetal bradycardia or absent heart rate
  • Gestational age <34 weeks

Differential Diagnosis

Other Causes of Third-Trimester Bleeding

ConditionKey Distinguishing Features
Placenta previaPainless bleeding, diagnosed on ultrasound
Vasa previaFetal hemorrhage, vessels over cervical os
Uterine rupturePrior uterine surgery, sudden severe pain, fetal distress
Cervical pathologyBleeding from cervix (polyps, cancer), cervical exam
Bloody show/laborAssociated with regular contractions, mucous
TraumaHistory of injury, placental abruption secondary

Comparison: Abruption vs Previa

FeaturePlacental AbruptionPlacenta Previa
PainSevere, constantPainless
BleedingDark, may be concealedBright red, always external
Uterine toneIncreased, tenderNormal
Fetal statusOften distressedUsually normal
UltrasoundMay not show clotDiagnostic for previa
CoagulopathyCommon in severeRare

Diagnostic Approach

Initial Assessment

Systematic Approach

  1. ABCs - maternal stabilization first
  2. Confirm fetal heart tones
  3. Assess vaginal bleeding (amount, character)
  4. Abdominal examination (uterine tenderness, tone)
  5. Avoid digital cervical exam until previa excluded

Laboratory Studies

TestPurposeCritical Values
CBCAnemia, platelet countHb drop, platelets <100k
Type & crossmatchBlood productsMatch 6+ units pRBCs
FibrinogenCoagulopathy<200 mg/dL concerning
PT/PTTCoagulation statusProlonged suggests DIC
D-dimerFibrinolysisElevated in DIC
BMPRenal functionCreatinine elevation
Kleihauer-BetkeFetal-maternal hemorrhageIf Rh-negative mother

Fetal Monitoring

Continuous Electronic Fetal Monitoring (EFM)

  • Essential for all suspected abruptions
  • Identify fetal distress early
  • Guide timing of delivery

Interpretation

PatternConcern Level
Reactive, normal variabilityReassuring
Tachycardia with reduced variabilityModerate
Repetitive late decelerationsSignificant
Prolonged bradycardiaCritical
Sinusoidal patternCritical

Imaging

Ultrasound

  • Sensitivity only 25-50% for abruption
  • May show:
    • Retroplacental clot (hypoechoic)
    • Elevated placental edge
    • Subchorionic collection
  • Normal ultrasound does NOT exclude abruption
  • Useful to exclude placenta previa

Clinical Diagnosis

  • Placental abruption is primarily a CLINICAL diagnosis
  • Do not delay treatment for imaging

Treatment

Initial Resuscitation

Maternal Stabilization

Step 1: Establish access
- Two large-bore IVs (16-18G)
- Consider central venous access if shock
- Blood samples for all labs including T&S

Step 2: Volume resuscitation
- Crystalloid 2L rapid infusion
- Activate massive transfusion protocol if:
  - Hypotension despite 2L crystalloid
  - Ongoing hemorrhage
  - Coagulopathy

Step 3: Blood product replacement
- pRBCs: Target Hb &gt;7 g/dL (&gt;8 if ongoing bleeding)
- FFP: 1:1 ratio with pRBCs in massive transfusion
- Cryoprecipitate: If fibrinogen &lt;200 mg/dL
- Platelets: If &lt;50,000/μL with bleeding

Step 4: Correct coagulopathy
- Target fibrinogen &gt;200 mg/dL
- Consider TXA if not yet delivered

Delivery Decision

Factors Influencing Mode and Timing

ScenarioManagement
Maternal hemodynamic instabilityEmergent cesarean section
Fetal distress (non-reassuring CTG)Emergent cesarean section
Fetal demiseConsider vaginal delivery if maternal stable
Stable mother + viable fetus + good CTGMay allow vaginal delivery
Preterm + mild abruption + stableConsider expectant with close monitoring

Cesarean Section Indications

  • Maternal hemodynamic instability
  • Fetal distress with viable fetus
  • Progression despite resuscitation
  • Unable to achieve rapid vaginal delivery

Vaginal Delivery Considerations

  • Appropriate if:
    • Maternal stability
    • No fetal distress OR fetal demise
    • Cervix favorable (dilated)
    • Close monitoring available
  • Avoid prolonged labor (risk of worsening)
  • Continuous EFM essential

Intraoperative Management

Cesarean Section Considerations

  • Anticipate increased blood loss (Couvelaire uterus)
  • Blood products available in OR
  • Uterotonic agents on standby
  • Consider B-lynch sutures for atony
  • Interventional radiology backup if available
  • Prepare for possible hysterectomy

Management of Coagulopathy

DIC Treatment

Goal: Replace consumed factors faster than consumption

1. Cryoprecipitate: 10 units
   - Contains fibrinogen, FVIII, vWF
   - Target fibrinogen &gt;200 mg/dL
   
2. FFP: 4-6 units
   - All clotting factors
   - 1:1 ratio with pRBCs in massive transfusion
   
3. Platelets: 1 apheresis unit
   - If &lt;50,000/μL with bleeding
   - Target &gt;50,000/μL
   
4. TXA (tranexamic acid): 1g IV
   - Antifibrinolytic
   - Give before delivery if possible

5. Monitor labs frequently
   - Repeat fibrinogen, PT/PTT, platelets q1-2h

Rh Prophylaxis

  • Kleihauer-Betke test to quantify fetal-maternal hemorrhage
  • RhoGAM for Rh-negative mothers
  • Standard dose: 300 mcg covers 30 mL fetal blood
  • Larger doses if significant hemorrhage

Disposition

ICU Admission Criteria

  • Hemodynamic instability requiring ongoing resuscitation
  • DIC or significant coagulopathy
  • Postpartum hemorrhage with ongoing transfusion needs
  • Multi-organ dysfunction
  • Couvelaire uterus with atony risk

Labor and Delivery Admission

  • All confirmed or suspected placental abruptions
  • Continuous fetal and maternal monitoring
  • Immediate OR availability

Post-Delivery Monitoring

Maternal

  • Serial hematocrit
  • Coagulation parameters
  • Urine output
  • Vital signs
  • Fundal tone (risk of atony)

Neonatal

  • Depends on gestational age and condition at delivery
  • NICU involvement for preterm or distressed newborn
  • Assess for anemia (may need transfusion)

Follow-up Recommendations

TimeframePurpose
24-48 hours postpartumEnsure hemostasis, correct anemia
2 weeks postpartumStandard postpartum visit
Pre-conception counselingRecurrence risk 5-15%
Next pregnancyEarly dating ultrasound, close monitoring

Patient Education

Understanding Placental Abruption

  • Placental abruption occurs when the placenta separates early
  • It is a serious condition requiring immediate medical care
  • Treatment focuses on stabilizing mother and baby
  • Delivery may be needed urgently depending on severity

Signs of Complications

Return Immediately If:

  • Heavy vaginal bleeding (soaking pad in 1 hour)
  • Severe abdominal or back pain
  • Decreased or absent fetal movement
  • Dizziness, lightheadedness
  • Fever or chills

Future Pregnancies

  • Recurrence risk is 5-15% (higher with severe abruption)
  • Close monitoring recommended in subsequent pregnancies
  • Avoid risk factors (smoking, cocaine, uncontrolled hypertension)
  • Regular prenatal care is essential

Risk Factor Modification

Modifiable Risk Factors

  • Stop smoking
  • Avoid cocaine and other recreational drugs
  • Control blood pressure
  • Maintain regular prenatal visits

Special Populations

Preterm Abruption

Considerations

  • Balance fetal immaturity vs abruption severity
  • Antenatal corticosteroids if 24-34 weeks and delivery not imminent
  • Magnesium sulfate for neuroprotection if <32 weeks
  • NICU consultation early

Expectant Management (Mild Abruption, Stable)

  • Possible if:
    • Hemodynamically stable
    • Reassuring fetal status
    • <34 weeks with no indication for immediate delivery
  • Requires:
    • Continuous monitoring initially
    • Close observation
    • Immediate OR availability

Hypertensive Disorders

  • Preeclampsia/eclampsia increases abruption risk 3-5 fold
  • Management of abruption may be complicated by:
    • Existing coagulopathy (HELLP)
    • Renal dysfunction
    • Hepatic dysfunction
  • Magnesium sulfate for seizure prophylaxis

Previous Cesarean Section

  • Increased risk of placental abnormalities
  • May have previa or accreta spectrum
  • Higher complexity surgery if needed

Trauma in Pregnancy

  • Abruption is major cause of fetal death after trauma
  • Can occur with minor trauma
  • Monitor 4-24 hours depending on severity
  • Fetal monitoring for at least 4 hours

Quality Metrics

Performance Indicators

MetricTarget
Time to fetal monitoring<10 minutes
Blood products available within<15 minutes
Fibrinogen checked100% of suspected abruptions
Time to cesarean (if indicated)<30 minutes
Rh status documented100%

Documentation Requirements

  • Estimated blood loss (vaginal and concealed)
  • Fetal heart rate and pattern
  • Uterine examination (tone, tenderness)
  • Coagulation status
  • Transfusion products given
  • Delivery decision rationale
  • Neonatal and maternal outcomes

Key Clinical Pearls

Diagnostic Pearls

  1. Clinical diagnosis - don't delay for imaging
  2. Concealed abruption may have minimal external bleeding
  3. Maternal tachycardia may be the first sign of significant hemorrhage
  4. Normal ultrasound does NOT exclude abruption
  5. Increasing fundal height suggests concealed hemorrhage

Management Pearls

  1. Fibrinogen is the most depleted factor - replace early
  2. 1:1:1 ratio of blood products in massive transfusion
  3. Early obstetric involvement is essential
  4. Fetal demise changes management - vaginal delivery usually possible
  5. Couvelaire uterus increases risk of postpartum atony

Disposition Pearls

  1. All suspected abruptions require admission
  2. Do not delay cesarean for coagulopathy - correct simultaneously
  3. Close postpartum monitoring - atony risk increased
  4. Counsel about recurrence before discharge
  5. Neonatal team involvement essential for preterm or distressed infant

References
  1. Oyelese Y, Ananth CV. Placental abruption. Obstet Gynecol. 2006;108(4):1005-1016.
  2. Downes KL, Grantz KL, Shenassa ED. Maternal, Labor, Delivery, and Perinatal Outcomes Associated with Placental Abruption: A Systematic Review. Am J Perinatol. 2017;34(10):935-957.
  3. Tikkanen M. Placental abruption: epidemiology, risk factors and consequences. Acta Obstet Gynecol Scand. 2011;90(2):140-149.
  4. American College of Obstetricians and Gynecologists. Practice Bulletin No. 183: Postpartum Hemorrhage. Obstet Gynecol. 2017.
  5. Ananth CV, Lavery JA, Vintzileos AM, et al. Severe placental abruption: clinical definition and associations with maternal complications. Am J Obstet Gynecol. 2016;214(2):272.e1-272.e9.

Version History
VersionDateChanges
1.02025-01-15Initial comprehensive version with 14-section template

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