Open Fracture
Summary
An open fracture (also called a compound fracture) is a broken bone where the broken ends have pierced through the skin, creating a direct connection between the fracture site and the outside environment. Think of a broken bone like a snapped stick—when the sharp ends break through the skin, bacteria from the outside can get into the bone, causing a high risk of infection. This is a serious orthopedic emergency that requires urgent treatment to prevent infection, preserve function, and ensure proper healing. Open fractures are classified by severity (Gustilo-Anderson classification), with higher grades having more soft tissue damage and higher infection risk. The key to management is immediate assessment (ABCs, neurovascular status), wound care (cover, don't probe), antibiotics (broad-spectrum), tetanus prophylaxis, urgent surgical debridement and fixation, and close monitoring for complications (infection, compartment syndrome, non-union). Most open fractures heal well with proper treatment, but infection remains a significant risk, especially in higher-grade injuries.
Key Facts
- Definition: Fracture with breach of skin/soft tissue, exposing bone
- Incidence: Common (5-10% of all fractures)
- Mortality: Low (<1%) unless complications (infection, vascular injury)
- Peak age: All ages, but more common in young adults (trauma)
- Critical feature: Broken bone visible through skin or wound communicates with fracture
- Key investigation: Clinical diagnosis, X-ray, assess for complications
- First-line treatment: Urgent surgical debridement, antibiotics, fixation
Clinical Pearls
"Time to surgery matters" — Open fractures should go to surgery within 6 hours ideally (golden period). Delayed treatment increases infection risk significantly.
"Don't probe the wound" — Never probe or extensively examine the wound in the emergency department. Cover it, give antibiotics, and get to surgery. Probing can push bacteria deeper.
"Gustilo classification predicts infection risk" — Grade I (low energy, small wound) has ~2% infection risk. Grade III (high energy, extensive soft tissue damage) has 10-50% infection risk.
"Always check neurovascular status" — Open fractures can have associated vascular or nerve injuries. Check pulses, sensation, movement immediately and repeatedly.
Why This Matters Clinically
Open fractures are serious injuries with high infection risk if not treated promptly and properly. Early recognition, appropriate wound care, antibiotics, and urgent surgical debridement are essential to prevent infection and preserve function. This is a condition that emergency and orthopedic clinicians manage, and prompt treatment can prevent serious complications.
Incidence & Prevalence
- Overall: Common (5-10% of all fractures)
- Trend: Stable (common in trauma)
- Peak age: All ages, but more common in young adults (trauma)
Demographics
| Factor | Details |
|---|---|
| Age | All ages, but more common in young adults (15-40 years) |
| Sex | Male predominance (trauma patterns) |
| Ethnicity | No significant variation |
| Geography | Higher in urban areas (trauma) |
| Setting | Emergency departments, trauma centers |
Risk Factors
Non-Modifiable:
- Age (young adults = more trauma)
- Male sex (trauma patterns)
Modifiable:
| Risk Factor | Relative Risk | Mechanism |
|---|---|---|
| High-energy trauma | 5-10x | More severe injury |
| Road traffic accidents | 3-5x | High-energy mechanism |
| Falls from height | 3-5x | High-energy mechanism |
| Gunshot wounds | 5-10x | High-energy, contamination |
| Farm/industrial injuries | 2-3x | Contamination risk |
Common Mechanisms
| Mechanism | Frequency | Typical Patient |
|---|---|---|
| Road traffic accidents | 40-50% | Young adults, high energy |
| Falls | 20-30% | Various ages |
| Sports injuries | 10-15% | Young adults |
| Gunshot wounds | 5-10% | Various |
| Other | 10-15% | Various |
The Injury Mechanism
Step 1: High-Energy Impact
- Force: High-energy force applied to bone
- Bone breaks: Fracture occurs
- Soft tissue damage: Surrounding tissues damaged
- Result: Bone breaks, soft tissues torn
Step 2: Skin Breach
- Bone ends: Sharp bone ends pierce skin
- Wound: Open wound created
- Contamination: Bacteria enter from outside
- Result: Fracture exposed to environment
Step 3: Infection Risk
- Bacteria: Enter through wound
- Bone exposure: Bone has poor blood supply
- Devitalized tissue: Dead tissue provides medium for bacteria
- Result: High infection risk
Step 4: Healing Challenges
- Infection: Can prevent healing
- Soft tissue loss: May need reconstruction
- Bone healing: May be delayed or fail (non-union)
- Result: Complex healing process
Classification (Gustilo-Anderson)
| Grade | Definition | Wound Size | Soft Tissue | Infection Risk |
|---|---|---|---|---|
| I | Low energy, clean wound | <1cm | Minimal | ~2% |
| II | Moderate energy, moderate wound | >1cm | Moderate | ~5% |
| IIIA | High energy, adequate soft tissue | Variable | Adequate coverage | ~10% |
| IIIB | High energy, inadequate soft tissue | Variable | Inadequate coverage, needs flap | ~20% |
| IIIC | High energy, vascular injury | Variable | Vascular injury | ~50% |
Anatomical Considerations
Common Sites:
- Tibia: Most common (thin skin, vulnerable)
- Femur: Less common but serious
- Radius/ulna: Common
- Other: Various
Why These Sites:
- Thin skin: More likely to breach
- Superficial bone: Less soft tissue protection
- High-energy mechanisms: More force
Symptoms: The Patient's Story
Typical Presentation:
History:
Signs: What You See
Vital Signs (May Be Abnormal):
| Sign | Finding | Significance |
|---|---|---|
| Temperature | Usually normal (may be elevated if infection) | Fever suggests infection |
| Heart rate | May be high (pain, blood loss) | Tachycardia |
| Blood pressure | May be low (blood loss) | Hypotension, shock |
General Appearance:
Local Examination:
| Finding | What It Means | Frequency |
|---|---|---|
| Open wound | Skin breach, bone visible or wound communicates | Always |
| Deformity | Obvious fracture deformity | 80-90% |
| Swelling | Soft tissue swelling | Common |
| Bruising | Soft tissue damage | Common |
| Bleeding | Active bleeding | Common |
Neurovascular Examination (Critical):
| Finding | What It Means | Significance |
|---|---|---|
| Pulses | Check distal pulses | Vascular injury if absent |
| Sensation | Check sensation | Nerve injury if abnormal |
| Movement | Check movement | Nerve/muscle injury if abnormal |
| Color | Check color | Ischemia if pale |
| Temperature | Check temperature | Ischemia if cold |
Signs of Complications:
Red Flags
[!CAUTION] Red Flags — Immediate Escalation Required:
- Signs of compartment syndrome — Medical emergency, needs urgent fasciotomy
- Signs of vascular injury (pulseless, pale, cold) — Medical emergency, needs urgent vascular repair
- Signs of nerve injury (numbness, weakness) — Needs urgent assessment
- Severe contamination — Higher infection risk, needs thorough debridement
- Delayed presentation (>6 hours) — Higher infection risk, needs urgent treatment
- Signs of infection — Needs urgent treatment, may need revision surgery
Structured Approach: ABCDE
A - Airway
- Assessment: Usually patent (unless other injuries)
- Action: Secure if compromised
B - Breathing
- Look: Usually normal (unless chest injury)
- Listen: Usually normal
- Measure: SpO2 (usually normal)
- Action: Support if needed
C - Circulation
- Look: May have blood loss (check for shock)
- Feel: Pulse (may be high), BP (may be low)
- Listen: Heart sounds (usually normal)
- Measure: BP (may be low), HR (may be high)
- Action: IV fluids if blood loss, control bleeding
D - Disability
- Assessment: Neurological status (GCS if head injury)
- Action: Assess if other injuries
E - Exposure
- Look: Full examination, check for other injuries
- Feel: Neurovascular status
- Action: Complete examination
Specific Examination Findings
Wound Examination (Limited):
- Don't probe: Never probe wound in ED
- Cover: Cover with sterile dressing
- Assess: Size, contamination, soft tissue damage (visual only)
- Document: Gustilo grade if possible
Neurovascular Examination (Critical):
- Pulses: Check distal pulses (doppler if needed)
- Sensation: Check sensation in distribution
- Movement: Check active movement
- Color: Check color
- Temperature: Check temperature
- Capillary refill: Check capillary refill
Signs of Compartment Syndrome:
- Pain: Severe, out of proportion
- Tense swelling: Hard, tense compartment
- Pain on passive stretch: Very painful
- Paresthesia: Numbness
- Pulses: Usually present (late sign if absent)
Special Tests
| Test | Technique | Positive Finding | Clinical Use |
|---|---|---|---|
| Neurovascular examination | Check pulses, sensation, movement | Abnormalities | Identifies complications |
| Compartment pressure | Measure compartment pressure | >30mmHg | Confirms compartment syndrome |
| Doppler | Check pulses with doppler | Absent pulses | Identifies vascular injury |
First-Line (Bedside) - Do Immediately
1. Clinical Diagnosis (Usually Obvious)
- History: Trauma, mechanism
- Examination: Open wound, deformity
- Action: Usually obvious, proceed to treatment
2. X-Ray (Essential)
- Purpose: Confirms fracture, assesses pattern
- Finding: Fracture visible, may show displacement
- Action: Essential before surgery
Laboratory Tests
| Test | Expected Finding | Purpose |
|---|---|---|
| Full Blood Count | May show anemia (blood loss) | Assesses blood loss |
| Group and Save/Crossmatch | Blood type | May need transfusion |
| Coagulation | Usually normal | Baseline |
| Urea & Electrolytes | Usually normal | Baseline |
Imaging
X-Ray (Essential):
| Indication | Finding | Clinical Note |
|---|---|---|
| All open fractures | Fracture pattern, displacement | Essential before surgery |
CT (If Needed):
| Indication | Finding | Clinical Note |
|---|---|---|
| Complex fractures | Detailed fracture pattern | If needed for planning |
| Joint involvement | Joint involvement | If suspected |
Angiography (If Vascular Injury):
| Indication | Finding | Clinical Note |
|---|---|---|
| Vascular injury suspected | Vascular injury | If pulses absent or abnormal |
Diagnostic Criteria
Clinical Diagnosis:
- Open wound + fracture (clinical or X-ray) = Open fracture
Gustilo Classification:
- Grade I: Clean wound <1cm, low energy
- Grade II: Wound >1cm, moderate energy
- Grade IIIA: High energy, adequate soft tissue
- Grade IIIB: High energy, inadequate soft tissue
- Grade IIIC: High energy, vascular injury
Management Algorithm
OPEN FRACTURE PRESENTATION
(Open wound + fracture)
↓
┌─────────────────────────────────────────────────┐
│ IMMEDIATE ASSESSMENT (ABCDE) │
│ • Airway, Breathing, Circulation │
│ • Control bleeding (pressure, not tourniquet) │
│ • Assess for other injuries │
└─────────────────────────────────────────────────┘
↓
┌─────────────────────────────────────────────────┐
│ WOUND CARE │
│ • Cover with sterile dressing │
│ • Don't probe wound │
│ • Don't reduce fracture (in ED) │
│ • Splint fracture │
└─────────────────────────────────────────────────┘
↓
┌─────────────────────────────────────────────────┐
│ NEUROVASCULAR ASSESSMENT │
│ • Check pulses (doppler if needed) │
│ • Check sensation │
│ • Check movement │
│ • Document findings │
└─────────────────────────────────────────────────┘
↓
┌─────────────────────────────────────────────────┐
│ ANTIBIOTICS │
│ • Broad-spectrum (co-amoxiclav or cefuroxime) │
│ • Give immediately │
│ • Continue until wound closure │
└─────────────────────────────────────────────────┘
↓
┌─────────────────────────────────────────────────┐
│ TETANUS PROPHYLAXIS │
│ • Check tetanus status │
│ • Give if not up to date │
└─────────────────────────────────────────────────┘
↓
┌─────────────────────────────────────────────────┐
│ URGENT SURGERY │
│ • Within 6 hours (golden period) │
│ • Debridement (remove dead tissue) │
│ • Irrigation (wash out) │
│ • Fixation (internal or external) │
│ • Wound management (closure or coverage) │
└─────────────────────────────────────────────────┘
↓
┌─────────────────────────────────────────────────┐
│ POST-OPERATIVE │
│ • Continue antibiotics │
│ • Monitor for infection │
│ • Monitor for compartment syndrome │
│ • Rehabilitation │
└─────────────────────────────────────────────────┘
Acute/Emergency Management - The First Hour
Immediate Actions (Do Simultaneously):
-
ABCs (Airway, Breathing, Circulation)
- Assess: Full ABCDE assessment
- Control bleeding: Pressure (not tourniquet unless life-threatening)
- Action: Resuscitate if needed
-
Wound Care
- Cover: Sterile dressing (don't probe)
- Splint: Splint fracture
- Don't reduce: Don't reduce in ED (do in surgery)
- Action: Protect wound, immobilize
-
Neurovascular Assessment
- Pulses: Check distal pulses (doppler if needed)
- Sensation: Check sensation
- Movement: Check movement
- Document: Document findings
- Action: Identify complications early
-
Antibiotics
- Broad-spectrum: Co-amoxiclav 1.2g IV or cefuroxime 1.5g IV
- Give immediately: Don't delay
- Continue: Until wound closure
-
Tetanus Prophylaxis
- Check status: Tetanus vaccination status
- Give if needed: Tetanus toxoid if not up to date
- Action: Prevent tetanus
-
Urgent Surgery
- Within 6 hours: Golden period
- Debridement: Remove dead tissue
- Irrigation: Wash out thoroughly
- Fixation: Internal or external fixation
- Wound: Closure or coverage
Medical Management
Antibiotics (Essential):
| Drug | Dose | Route | Duration | Notes |
|---|---|---|---|---|
| Co-amoxiclav | 1.2g | IV | TDS | Until wound closure |
| Cefuroxime | 1.5g | IV | TDS | Alternative |
| Gentamicin | 5mg/kg | IV | OD | Add if severe (Grade III) |
Mechanism: Prevents infection
Tetanus Prophylaxis:
| Status | Action |
|---|---|
| Up to date | None needed |
| Not up to date | Tetanus toxoid |
| Unknown | Tetanus toxoid |
Analgesia:
| Drug | Dose | Route | Notes |
|---|---|---|---|
| Morphine | 5-10mg | IV | As needed |
| Paracetamol | 1g | IV/PO | Regular |
| NSAIDs | As appropriate | PO | If no contraindications |
Surgical Management
Debridement (Essential):
- Remove: All dead tissue, foreign material
- Irrigate: Thorough irrigation
- Assess: Viability of tissues
Fixation:
- Internal: Plates, screws (if soft tissue allows)
- External: External fixator (if severe soft tissue damage)
- Timing: Usually immediate (primary fixation) or delayed (if severe)
Wound Management:
- Primary closure: If clean, low grade (Grade I)
- Delayed closure: If contaminated, high grade (Grade II-III)
- Flap coverage: If soft tissue loss (Grade IIIB)
Disposition
Admit to Hospital:
- All open fractures: Need surgery, monitoring
- Regular follow-up: Monitor for infection, healing
Discharge Criteria:
- Not applicable: All need admission and surgery
Follow-Up:
- Wound: Monitor for infection
- Healing: Monitor bone healing
- Rehabilitation: Start early
- Long-term: May need further surgery
Immediate (Days-Weeks)
| Complication | Incidence | Presentation | Management |
|---|---|---|---|
| Infection | 2-50% (depends on grade) | Redness, discharge, fever | Debridement, antibiotics, may need removal of metalwork |
| Compartment syndrome | 5-10% | Severe pain, tense swelling | Urgent fasciotomy |
| Vascular injury | 5-10% | Absent pulses, ischemia | Urgent vascular repair |
| Nerve injury | 10-20% | Numbness, weakness | May recover, may need repair |
Infection:
- Mechanism: Bacteria enter through wound
- Management: Debridement, antibiotics, may need removal of metalwork
- Prevention: Early surgery, antibiotics, proper debridement
Compartment Syndrome:
- Mechanism: Swelling increases pressure
- Management: Urgent fasciotomy
- Prevention: Monitor, early recognition
Early (Weeks-Months)
1. Delayed Union (10-20%)
- Mechanism: Bone doesn't heal in expected time
- Management: May need further surgery
- Prevention: Proper fixation, infection control
2. Non-Union (5-10%)
- Mechanism: Bone doesn't heal
- Management: Bone graft, revision fixation
- Prevention: Proper fixation, infection control
3. Malunion (5-10%)
- Mechanism: Bone heals in wrong position
- Management: May need correction
- Prevention: Proper reduction, fixation
Late (Months-Years)
1. Chronic Infection (2-5%)
- Mechanism: Persistent infection
- Management: Long-term antibiotics, may need removal of metalwork
- Prevention: Early treatment, proper debridement
2. Osteomyelitis (2-5%)
- Mechanism: Bone infection
- Management: Long-term antibiotics, debridement
- Prevention: Early treatment, infection control
3. Functional Impairment (10-20%)
- Mechanism: Residual disability
- Management: Rehabilitation, may need further surgery
- Prevention: Early rehabilitation, proper treatment
Natural History (Without Treatment)
Untreated Open Fracture:
- High infection risk: Almost certain infection
- Poor healing: Non-union likely
- Functional loss: Significant disability
Outcomes with Treatment
| Variable | Outcome | Notes |
|---|---|---|
| Infection | 2-50% (depends on grade) | Lower with proper treatment |
| Union | 80-90% | Most heal with proper treatment |
| Functional recovery | 70-80% | Most regain good function |
| Mortality | <1% | Very low unless complications |
Factors Affecting Outcomes:
Good Prognosis:
- Early treatment: Better outcomes (<6 hours)
- Low grade: Grade I-II have better outcomes
- Proper debridement: Reduces infection risk
- No complications: Better outcomes
Poor Prognosis:
- Delayed treatment: Higher infection risk
- High grade: Grade III have worse outcomes
- Complications: Infection, compartment syndrome worsen outcomes
- Severe contamination: Higher infection risk
Prognostic Factors
| Factor | Impact on Prognosis | Evidence Level |
|---|---|---|
| Time to surgery | <6 hours = better | High |
| Gustilo grade | Lower grade = better | High |
| Proper debridement | Better outcomes | High |
| Complications | Complications = worse | High |
Key Guidelines
1. BOA Guidelines (2017) — Standards for the management of open fractures. British Orthopaedic Association
Key Recommendations:
- Urgent surgery within 6 hours
- Broad-spectrum antibiotics
- Proper debridement
- Evidence Level: 1A
2. EAST Guidelines (2012) — Management of open fractures. Eastern Association for the Surgery of Trauma
Key Recommendations:
- Urgent debridement
- Antibiotics
- Evidence Level: 1A
Landmark Trials
Multiple studies on timing of surgery, antibiotic use, infection prevention.
Evidence Strength
| Intervention | Level | Key Evidence | Clinical Recommendation |
|---|---|---|---|
| Urgent surgery | 1A | Multiple studies | Within 6 hours |
| Antibiotics | 1A | Multiple RCTs | Essential |
| Debridement | 1A | Universal | Essential |
What is an Open Fracture?
An open fracture (also called a compound fracture) is a broken bone where the broken ends have pierced through the skin, creating a direct connection between the fracture and the outside. Think of a broken bone like a snapped stick—when the sharp ends break through the skin, bacteria from the outside can get into the bone, causing a high risk of infection.
In simple terms: Your bone is broken and the broken ends have come through the skin. This is serious because it can get infected, but with proper treatment, most people recover well.
Why does it matter?
Open fractures are serious injuries with a high risk of infection if not treated promptly and properly. Early treatment (surgery to clean the wound and fix the bone) is essential to prevent infection and ensure proper healing. The good news? With proper treatment, most people recover well and regain good function.
Think of it like this: It's like breaking a bone and the sharp ends cutting through your skin—it needs urgent treatment to prevent infection and help it heal properly.
How is it treated?
1. Immediate Care:
- Wound: The wound will be covered with a sterile dressing (don't touch it)
- Splint: The fracture will be splinted to keep it still
- Antibiotics: You'll get antibiotics immediately to prevent infection
- Tetanus: You'll get a tetanus shot if needed
2. Urgent Surgery:
- When: Usually within 6 hours (the sooner the better)
- What: The surgeon will clean the wound thoroughly (remove dead tissue, wash it out), fix the bone (with metal plates/screws or an external frame), and manage the wound (may leave it open initially if contaminated)
- Why: To prevent infection and help the bone heal properly
3. After Surgery:
- Antibiotics: You'll continue antibiotics until the wound is closed
- Monitoring: You'll be monitored for infection and other complications
- Rehabilitation: You'll start rehabilitation to regain function
The goal: Prevent infection, help the bone heal properly, and regain function.
What to expect
Recovery:
- Surgery: Usually within 6 hours of injury
- Hospital stay: Usually a few days to weeks (depends on severity)
- Wound: May be left open initially, closed later if needed
- Bone healing: Usually takes weeks to months
After Treatment:
- Wound: Will be monitored for infection
- Bone: Will be monitored for healing
- Rehabilitation: Will start early to regain function
- Follow-up: Regular follow-up to monitor progress
Recovery Time:
- Wound healing: Usually weeks
- Bone healing: Usually months (6-12 weeks or longer)
- Full recovery: Usually months to a year
When to seek help
This is already an emergency — If you have an open fracture, you should already be in the hospital getting treatment.
After treatment, see your doctor if:
- Your wound becomes red, swollen, or has discharge
- You have a fever
- You have increasing pain
- You have concerns about your recovery
Call 999 (or your emergency number) immediately if:
- You have severe pain that's getting worse
- Your limb becomes pale, cold, or numb
- You feel very unwell
- You have signs of infection (redness, discharge, fever)
Remember: Open fractures are serious injuries that need urgent treatment. If you have an open fracture, you should be in the hospital getting treatment. After treatment, follow your doctor's advice and watch for signs of infection or other complications.
Primary Guidelines
-
British Orthopaedic Association. Standards for the management of open fractures. BOA. 2017.
-
Eastern Association for the Surgery of Trauma. Management of open fractures. EAST Practice Management Guidelines. 2012.
Key Trials
- Multiple studies on timing of surgery, antibiotic use, and infection prevention.
Further Resources
- BOA Guidelines: British Orthopaedic Association
Last Reviewed: 2025-12-25 | MedVellum Editorial Team
Medical Disclaimer: MedVellum content is for educational purposes and clinical reference. Clinical decisions should account for individual patient circumstances. Always consult appropriate specialists. This information is not a substitute for professional medical advice, diagnosis, or treatment.