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Major Trauma

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Overview

Major Trauma

Quick Reference

Critical Alerts

  • ABCDE approach saves lives: Systematic primary survey identifies life threats
  • Hemorrhage is leading preventable death: Control bleeding early
  • Permissive hypotension for hemorrhage: Target SBP 80-90 until surgical control (except TBI)
  • Massive transfusion protocol: 1:1:1 ratio of RBC:FFP:Platelets
  • TXA within 3 hours: Reduces mortality if given early
  • Log-roll with C-spine precautions: Until cleared

Key Diagnostics

TestPurpose
eFASTFree fluid (abdomen, thorax) at bedside
CXR portablePneumo/hemothorax, widened mediastinum
Pelvis XRPelvic fracture
CT Pan-scanDefinitive imaging when stable enough
Blood gas/lactateShock, perfusion status
Type and crossmatchBlood availability

Emergency Treatments

ConditionTreatmentDetails
Airway obstructionRSI with C-spine stabilizationVideo laryngoscopy preferred
Tension pneumothoraxNeedle/Finger thoracostomy2nd ICS MCL or 5th ICS MAL
HemorrhageDirect pressure, tourniquets, MTPControl bleeding, replace blood
TXA1g IV bolusWithin 3 hours of injury
Pelvic fracturePelvic binderImmediate stabilization

Definition

Overview

Major trauma (polytrauma) refers to injury to multiple body systems with at least one potentially life-threatening injury. It requires a systematic approach using ATLS (Advanced Trauma Life Support) principles, with simultaneous assessment and resuscitation. The goal is to identify and treat immediately life-threatening conditions while preparing for definitive care.

Criteria for Trauma Team Activation

Physiological Criteria:

  • GCS ≤13
  • SBP <90 mmHg
  • RR <10 or >29 (or intubated)
  • Penetrating injury to head, neck, torso, extremities proximal to knee/elbow

Anatomical Criteria:

  • Flail chest
  • Two or more proximal long bone fractures
  • Crushed, degloved, or mangled extremity
  • Amputation proximal to wrist or ankle
  • Pelvic fracture
  • Open or depressed skull fracture
  • Paralysis

Mechanism Criteria:

  • Fall >20 feet (6 meters)
  • High-speed MVC (>40 mph with intrusion, ejection, rollover)
  • Motorcycle crash >20 mph
  • Pedestrian/cyclist struck at significant speed
  • Death in same vehicle
  • Extrication time >20 minutes

Classification by Injury Severity

Score (ISS)Category
1-8Minor
9-15Moderate
16-24Severe
≥25Critical
>0Usually fatal

Epidemiology

  • Leading cause of death: Ages 1-44 years
  • Global deaths: 4.4 million annually from injuries
  • Trimodal death distribution:
    • Immediate (50%): At scene from severe brain/vascular injury
    • Early (30%): Within hours from hemorrhage, airway compromise
    • Late (20%): Days to weeks from sepsis, MODS

Pathophysiology

Lethal Triad of Trauma

FactorMechanismEffect
HypothermiaHeat loss, cold fluids, exposureCoagulopathy, cardiac dysfunction
AcidosisHypoperfusion, anaerobic metabolismCoagulopathy, myocardial depression
CoagulopathyDilution, consumption, hypothermiaContinued bleeding

Damage Control Resuscitation: Addresses lethal triad

  • Permissive hypotension (until surgical control)
  • Minimal crystalloid
  • Balanced blood product transfusion
  • Early hemorrhage control

Hemorrhagic Shock Classes

ClassBlood LossHeart RateBPRRUOPMental Status
I<15% (<750 mL)<100Normal14-20>0Normal
II15-30% (750-1500 mL)100-120Normal20-3020-30Anxious
III31-40% (1500-2000 mL)120-140Decreased30-405-15Confused
IV>40% (>000 mL)>40Severely decreased>5MinimalLethargic

Inflammatory Response

  • Massive tissue injury → systemic inflammation
  • Can progress to ARDS, MODS
  • Balance between control of injury and minimizing second hit

Clinical Presentation

Pre-Hospital Information

MIST Handover:

Primary Survey (ABCDE)

A - Airway with C-Spine Protection:

FindingAction
Stridor, snoringJaw thrust, suction, adjuncts
Blood/debris in airwaySuction, position
Facial trauma, burnsEarly intubation
Unable to maintainDefinitive airway (RSI)

B - Breathing:

FindingConcernAction
Tracheal deviation, distended neck veins, absent breath soundsTension pneumothoraxFinger/needle thoracostomy
Dullness, decreased breath soundsMassive hemothoraxChest tube
Paradoxical chest wall movementFlail chestO2, analgesia, consider intubation
Open chest woundOpen pneumothoraxThree-sided occlusive dressing

C - Circulation:

FindingConcernAction
Hypotension + tachycardiaHemorrhagic shockIV access, blood products, find source
External bleedingHemorrhageDirect pressure, tourniquet
Distended neck veins + hypotensionCardiac tamponade or tension pneumoPericardiocentesis/thoracostomy
Pelvic instabilityPelvic fracturePelvic binder
Positive eFASTIntra-abdominal bloodOR for laparotomy or damage control

D - Disability:

FindingConcern
Decreased GCSTBI
Unequal pupilsHerniation
Focal deficitsSpinal cord injury

E - Exposure/Environmental Control:

Secondary Survey

After primary survey stabilization:

Physical Examination:

AreaKey Findings
HeadLacerations, Battle's sign, raccoon eyes, CSF leak
FaceMidface instability, dental trauma
NeckC-spine tenderness, tracheal deviation, JVD
ChestRib crepitus, paradoxical movement, wounds
AbdomenDistension, tenderness, seat belt sign
PelvisInstability (test ONCE only), perineal injury
ExtremitiesDeformity, open fractures, pulses
Back (log roll)Step-off, bruising, rectal exam if indicated

Mechanism of injury
Common presentation.
Injuries suspected or identified
Common presentation.
Signs (vitals, GCS)
Common presentation.
Treatment given
Common presentation.
Red Flags

Immediate Life Threats

ConditionKey FindingAction
Airway obstructionStridor, inability to speakAirway management
Tension pneumothoraxHypotension + JVD + absent breath soundsDecompression
Massive hemothorax>500 mL from chest tubeThoracotomy
Cardiac tamponadeBeck's triad (muffled sounds, JVD, hypotension)Pericardiocentesis/OR
Open pneumothoraxSucking chest woundOcclusive dressing
Flail chest with respiratory failureParadoxical movementIntubation, PEEP
Massive hemorrhageShock with identified sourceOR, IR, MTP
Unstable pelvic fractureHypotension + pelvic instabilityBinder, embolization

Indicators of Severe Injury

  • GCS ≤8
  • SBP <90 despite fluids
  • Lactate >4
  • Base deficit worse than -6
  • Need for massive transfusion

Diagnostic Approach

Bedside Diagnostics

eFAST (Extended Focused Assessment with Sonography for Trauma):

ViewPurpose
RUQ (Morison's pouch)Hepatorenal blood
LUQ (Splenorenal)Perisplenic blood
Pelvis (suprapubic)Pelvic blood
Cardiac (subxiphoid/parasternal)Pericardial effusion
Thoracic (bilateral)Hemothorax, pneumothorax

Interpretation:

  • Positive eFAST in unstable patient → OR
  • Negative eFAST doesn't exclude injury (hollow viscus, retroperitoneal)

Portable Imaging:

  • CXR: Pneumothorax, hemothorax, widened mediastinum
  • Pelvis XR: Pelvic fracture

Laboratory Studies

TestPurpose
Type and crossmatchBlood availability
CBCBaseline Hgb (may be normal initially)
Coagulation (PT, PTT, fibrinogen)Coagulopathy
BMPElectrolytes, renal function
ABG/VBG with lactatePerfusion, acidosis
TroponinCardiac contusion
LipasePancreatic injury
Pregnancy testAll females of childbearing age

CT Imaging ("Pan-Scan")

When Patient Stabilized:

StudyPurpose
CT HeadTBI, skull fracture
CT C-SpineCervical injury
CT ChestThoracic injury
CT Abdomen/Pelvis with contrastSolid organ, bowel, vascular injury
CT AngiographyVascular injury if suspected

CT Should NOT Delay:

  • OR for unstable hemodynamics
  • Critical interventions

Treatment

Damage Control Resuscitation

Principles:

  1. Permissive hypotension (SBP 80-90) until surgical control (except TBI)
  2. Limit crystalloid (avoid dilutional coagulopathy)
  3. Balanced transfusion (1:1:1 RBC:FFP:Platelets)
  4. Early TXA (within 3 hours)
  5. Prevent hypothermia

Massive Transfusion Protocol (MTP):

Trigger Criteria
Requiring > units RBC in 1 hour
ABC Score ≥2 (HR >20, SBP ≤90, penetrating mechanism, positive eFAST)
Obvious massive hemorrhage

Transfusion Ratio:

  • 1:1:1 (RBC : FFP : Platelets)
  • Or 6:4:1 unit ratio

Tranexamic Acid (TXA):

  • 1g IV over 10 minutes within 3 hours of injury
  • Then 1g over 8 hours
  • Proven mortality benefit in bleeding trauma

Airway Management

Indications for Intubation:

  • Airway obstruction
  • GCS ≤8
  • Respiratory failure
  • Anticipated clinical course
  • Need for safe transfer/imaging

RSI Technique:

  • C-spine inline stabilization (remove front of collar)
  • Video laryngoscopy preferred
  • Have surgical airway ready

Chest Trauma Interventions

ConditionIntervention
Tension pneumothoraxFinger thoracostomy → chest tube
Open pneumothoraxThree-sided dressing → chest tube
Massive hemothoraxChest tube (large bore 32-36F) → consider thoracotomy
Cardiac tamponadePericardiocentesis or ED thoracotomy
Flail chestIntubation + PEEP if failing

ED (Resuscitative) Thoracotomy:

IndicationPurpose
Penetrating trauma with arrest or near-arrestCardiac massage, aortic cross-clamp, tamponade release
Blunt traumaMuch lower survival; selective use

Hemorrhage Control

External Hemorrhage:

  • Direct pressure
  • Tourniquets (life limb extremity bleeding)
  • Wound packing with hemostatic agents

Internal Hemorrhage:

SourceIntervention
ThoraxChest tube; thoracotomy if >1500 mL initial or >00 mL/hr
AbdomenDamage control laparotomy; OR
PelvisPelvic binder → IR angioembolization or preperitoneal packing
RetroperitoneumOften non-operative or IR

Pelvic Fracture Management

Immediate Actions:

  • Pelvic binder (reduce volume, tamponade bleeding)
  • Avoid log-roll (can displace clot)
  • MTP if hemorrhagic shock

Definitive Options:

  • Angioembolization (arterial bleeding)
  • Preperitoneal packing (venous bleeding)
  • External fixation

C-Spine Management

Immobilization:

  • Maintain until cleared clinically or radiographically
  • Collar + spine board (limit time on board)

Clearance:

  • NEXUS criteria or Canadian C-Spine Rule
  • If not clinically clearable → CT C-spine

Disposition

Immediate OR Indications

  • Positive eFAST with hemodynamic instability
  • Massive hemothorax
  • Class III-IV hemorrhagic shock with identified surgical source
  • Penetrating torso trauma with instability
  • ED thoracotomy survivors

ICU Admission

  • All major trauma
  • Need for mechanical ventilation
  • Ongoing resuscitation
  • Monitoring for delayed complications

Transfer Considerations

  • Transfer to trauma center if Level I/II care not available
  • Stabilize before transfer
  • Do not delay transfer for non-essential imaging

Tertiary Survey

Within 24 Hours:

  • Repeat head-to-toe exam
  • Review all imaging
  • Identify missed injuries (up to 10% initially missed)

Patient/Family Education

Condition Explanation

  • "Your family member has been seriously injured in multiple parts of the body."
  • "We are focusing on stopping any bleeding and making sure they can breathe."
  • "They may need surgery and will be in the intensive care unit."

Expected Course

  • Multiple surgeries may be needed
  • ICU stay likely prolonged
  • Rehabilitation will be important
  • Psychological support available

Involvement

  • Designated family contact for updates
  • Social work and chaplain services
  • ICU family meetings

Special Populations

Pediatric Trauma

  • Higher surface area to volume → rapid heat loss
  • Blood volume ~80 mL/kg
  • Immature skeleton → internal injury without fractures
  • Head is disproportionately large
  • Cardiac output depends on heart rate

Geriatric Trauma

  • Lower physiologic reserve
  • Pre-existing anticoagulation
  • May not mount tachycardia (beta-blockers)
  • Consider TBI with even minor mechanism
  • Frailty impacts outcomes

Pregnant Trauma Patients

  • Prioritize mother: Best care for fetus is care for mother
  • Left lateral tilt or manual uterine displacement
  • Rhogam if Rh-negative
  • Obstetrics consultation
  • Early fetal monitoring
  • Emergency cesarean if maternal arrest and >24 weeks

Anticoagulated Patients

  • Reverse anticoagulation early
  • 4-factor PCC for warfarin
  • Idarucizumab for dabigatran
  • TXA still indicated

Burns + Trauma

  • Airway priority (inhalation injury)
  • Fluid resuscitation for burns
  • Escharotomy for circumferential burns

Quality Metrics

Performance Indicators

MetricTarget
Primary survey completion<10 minutes
Time to OR for unstable patient<60 minutes
TXA administration within 3 hours>0%
MTP activated appropriately100% when indicated
Tertiary survey within 24h100%
Hypothermia prevention documented100%

Documentation Requirements

  • Mechanism and pre-hospital information
  • Primary survey findings
  • Secondary survey findings
  • Imaging and lab results
  • Procedures performed
  • Blood products given
  • Time stamps for key interventions

Key Clinical Pearls

Diagnostic Pearls

  • Primary survey is treatment: Intervene as you find problems
  • eFAST positive + unstable = OR: Don't delay for CT
  • Lactate is a resuscitation marker: Rising lactate = ongoing hypoperfusion
  • Don't trust initial hemoglobin: May be normal despite massive blood loss
  • Log-roll to examine the back: Don't miss posterior injuries
  • CT pan-scan when stable: Identifies occult injuries

Treatment Pearls

  • Lethal triad kills: Warm, stop acidosis, give blood
  • Permissive hypotension: SBP 80-90 until bleeding controlled (NOT in TBI)
  • TXA works: Give within 3 hours
  • 1:1:1 transfusion: Don't resuscitate with crystalloid
  • Pelvic binder early: For pelvic fractures
  • ED thoracotomy has role: Penetrating arrest with brief down time

Disposition Pearls

  • All major trauma to trauma center: Transfer if needed
  • Tertiary survey finds missed injuries: Do within 24 hours
  • ICU admission standard: For monitoring and ongoing resuscitation
  • Family communication early: Assign liaison

References
  1. American College of Surgeons Committee on Trauma. ATLS: Advanced Trauma Life Support Student Course Manual, 10th ed. 2018.
  2. CRASH-2 Trial Collaborators. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients. Lancet. 2010;376(9734):23-32.
  3. Holcomb JB, et al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma. JAMA. 2015;313(5):471-482.
  4. Spahn DR, et al. The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition. Crit Care. 2019;23(1):98.
  5. Cannon JW, et al. Damage Control Resuscitation. J Trauma Acute Care Surg. 2020;89(2S):S168-S174.
  6. Fox EE, et al. Earlier endpoints are required for hemorrhagic shock trials among severely injured patients. Shock. 2017;47(5):567-573.
  7. Brenner M, et al. Resuscitative endovascular balloon occlusion of the aorta and resuscitative thoracotomy. J Trauma Acute Care Surg. 2018;85(6):1013-1019.
  8. UpToDate. Initial management of trauma in adults. 2024.

At a Glance

EvidenceStandard
Last UpdatedRecently

Guidelines

  • NICE Guidelines
  • BTS Guidelines
  • RCUK Guidelines