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Neurosurgery
Emergency Medicine
Trauma
EMERGENCY

Extradural Haemorrhage (EDH)

High EvidenceUpdated: 2025-12-24

On This Page

Red Flags

  • Lucid Interval ("Talk and Die")
  • Fixed Dilated Pupil (Uncal Herniation)
  • Cushing's Triad (Hypertension, Bradycardia, Irregular Respiration)
  • Rapid GCS Decline
Overview

Extradural Haemorrhage (EDH)

1. Topic Overview (Clinical Overview)

Summary

Extradural Haemorrhage (EDH) is an arterial bleed (Most commonly from the Middle Meningeal Artery) located between the skull and the dura mater. It typically follows trauma (Blow to the temporal region – Pterion). The haematoma does NOT cross suture lines (Dura is adherent). On CT, it appears as a biconvex ("Lemon-shaped") hyperdense collection. The classic presentation is the "Lucid Interval" – Initial loss of consciousness -> Apparent recovery -> Rapid deterioration and death as the haematoma expands and causes uncal herniation (Compression of CN III leading to ipsilateral dilated pupil, then brainstem compression). This is a neurosurgical emergency; emergency craniotomy and evacuation is life-saving. Prognosis is excellent if treated before herniation ("Talk and Die" syndrome occurs when recognition is delayed).

Key Facts

  • Location: Between Skull and Dura Mater.
  • Aetiology: Trauma to Pterion (Temporoparietal).
  • Vessel: Middle Meningeal Artery (Most common). Venous (Rarer, often posterior fossa).
  • CT Appearance: Biconvex (Lemon-shaped). Hyperdense. Does NOT cross suture lines.
  • Lucid Interval: "Talk and Die" – Initial LOC -> Recovery -> Deterioration.
  • Herniation Signs: Ipsilateral Fixed Dilated Pupil (CN III), Contralateral Hemiparesis, Cushing's Triad.
  • Treatment: Emergency Craniotomy and Evacuation.

Clinical Pearls

"Lemon Shape = Extradural": Biconvex. Subdural is crescent-shaped.

"Lucid Interval = High Index of Suspicion": Patient who was knocked out, wakes up, then deteriorates rapidly.

"Blown Pupil = Ipsilateral to Lesion": CN III compressed against tentorium.

"Does NOT Cross Sutures": Dura is adherent at suture lines.

Why This Matters Clinically

EDH is one of the most treatable neurosurgical emergencies. Prompt recognition and surgery can result in complete recovery; delay leads to death.


2. Epidemiology

Incidence

  • 1-4% of Head Injuries.
  • Peak Age: Young adults (20-30 years). Trauma-prone.
  • Rare in Infants/Elderly: Dura more adherent to skull at extremes of age.
  • Mortality: ~5-10% if treated. ~90%+ if untreated/delayed.

3. Anatomy & Pathophysiology

Pterion

FeatureNotes
LocationTemple region. Junction of Frontal, Parietal, Temporal, Sphenoid bones.
WeaknessThinnest part of skull. Overlies Middle Meningeal Artery.
TraumaBlow to temple -> Skull fracture -> MMA laceration -> EDH.

Middle Meningeal Artery (MMA)

FeatureNotes
OriginBranch of Maxillary Artery (ECA).
CourseEnters skull via Foramen Spinosum. Runs in groove on inner skull.
SignificanceArterial bleeding -> Rapid accumulation of blood.

Haematoma Formation

  • Stripping of dura from skull as blood accumulates.
  • Dura adherent at suture lines -> Biconvex shape. Does NOT cross sutures.
  • Volume increases rapidly (Arterial).
  • Mass effect -> Raised ICP -> Herniation.

Uncal Herniation

StagePathologyClinical Sign
1Uncus of temporal lobe compresses CN III.Ipsilateral dilated pupil (Parasympathetic fibres first).
2Cerebral peduncle compressed against tentorium.Contralateral hemiparesis (Ipsilateral false localising if Kernohan's notch).
3Brainstem compression.Cushing's Triad. Coma. Death.

Cushing's Triad (Late Sign of Raised ICP)

FeatureNotes
HypertensionReflex to maintain cerebral perfusion.
BradycardiaBaroreceptor response.
Irregular Respiration (Cheyne-Stokes)Brainstem dysfunction.

4. Clinical Presentation

Classic "Lucid Interval"

PhaseDescription
Initial ImpactLoss of Consciousness (Brief).
Lucid IntervalRecovery. Alert. May appear well. (Minutes to Hours).
DeteriorationHeadache. Vomiting. Confusion. Seizures. GCS falls. Pupil dilates. Death.

Lucid interval is classic but NOT always present.

Symptoms

SymptomNotes
HeadacheWorsening.
Nausea / VomitingRaised ICP.
Confusion / Altered Consciousness
Seizures

Signs

SignNotes
GCS DeclineProgressive.
Ipsilateral Dilated PupilCN III compression. Fixed and unreactive ("Blown").
Contralateral HemiparesisCerebral peduncle compression.
Cushing's TriadLate. Ominous.
Scalp Injury / HaematomaOver temple (Pterion).

5. Investigations

CT Head (Non-Contrast) – URGENT

FindingDescription
Biconvex (Lentiform) Collection"Lemon-shaped". High density (Acute blood).
Does NOT Cross Suture LinesDura adherent at sutures.
Mass EffectMidline shift. Compression of lateral ventricle.
Skull FractureOften overlying temporal bone.

Comparison: EDH vs SDH

FeatureEDH (Extradural)SDH (Subdural)
ShapeBiconvex (Lemon).Crescent (Banana).
Suture LinesDoes NOT cross.DOES cross.
LocationBetween Skull and Dura.Between Dura and Arachnoid.
AetiologyArterial (MMA). Trauma.Venous (Bridging veins). Trauma. Elderly.
SpeedRapid accumulation.Slower (Acute, Subacute, Chronic).

6. Management

Principles (EMERGENCY)

  1. ABCDE Approach (Trauma resuscitation).
  2. Avoid Secondary Brain Injury (Maintain BP, Oxygenation, Normoglycaemia).
  3. Urgent CT Head.
  4. Emergency Neurosurgery (Craniotomy).
  5. Post-Op ICU Care.

Pre-Hospital / A&E

InterventionDetail
AirwayProtect. Intubate if GCS ≤8.
BreathingOxygenate. Avoid hypoxia.
CirculationAvoid hypotension (SBP >0).
GCS MonitoringFrequent. Document changes.
Urgent TransferTo Neurosurgical centre.

Medical Measures (Bridge to Surgery)

MeasureDetail
Head Elevation30 degrees (If spine cleared).
IV Mannitol (Or Hypertonic Saline)Reduce ICP temporarily.
Anti-EpilepticsIf seizures.
Avoid Hyperthermia

Surgical Management

ProcedureDetail
CraniotomyBone flap raised. Haematoma evacuated. MMA cauterised/ligated.
Burr HolesMay be used as emergency drainage (If delay to craniotomy).

Indications for Surgery (NICE/SBNS)

IndicationNotes
EDH >0ml
Thickness >5mm
Midline Shift >mm
GCS <9 with pupil asymmetry
Any symptomatic / deteriorating patient

Conservative management may be appropriate for small EDH (<30ml, <15mm, No shift, GCS 15) with close observation and repeat imaging.


7. Complications
ComplicationNotes
Uncal HerniationDeath if untreated.
Brain Death
Seizures
Post-Operative InfectionMeningitis. Abscess.
Re-Accumulation
Neurological DeficitIf delayed treatment.

8. Prognosis & Outcomes
ScenarioOutcome
Early Surgery (Before Herniation)Excellent. Near-complete recovery expected.
Delayed Surgery / Post-HerniationHigh mortality / Significant disability.
"Talk and Die"Patients who deteriorate after initial lucidity – Highlights need for vigilance.

9. Differential Diagnosis
ConditionDistinguishing Features
Subdural Haematoma (SDH)Crescent-shaped. Crosses sutures. Slower. Elderly.
Subarachnoid Haemorrhage (SAH)"Thunderclap" headache. Starfish pattern. Aneurysm.
Intracerebral Haemorrhage (ICH)Hypertension. Intraparenchymal blood.
ContusionBruising of brain parenchyma.
Diffuse Axonal Injury (DAI)Shearing. Multiple small haemorrhages.

10. Evidence & Guidelines

Key Guidelines

GuidelineOrganisationNotes
NICE NG232NICEHead Injury: Assessment and Early Management.
SBNSSociety of British Neurological SurgeonsIndications for surgery.

11. Exam Scenarios

Scenario 1:

  • Stem: A young man is hit on the side of the head. He was briefly unconscious, then fully recovered (Lucid interval), then suddenly becomes unresponsive with a fixed dilated left pupil. CT shows a biconvex hyperdense lesion. What is the diagnosis and immediate management?
  • Answer: Extradural Haemorrhage. Emergency Craniotomy and Evacuation.

Scenario 2:

  • Stem: What vessel is most commonly injured in EDH?
  • Answer: Middle Meningeal Artery.

Scenario 3:

  • Stem: What is the CT appearance of an EDH, and why does it NOT cross suture lines?
  • Answer: Biconvex (Lemon-shaped) collection. Does NOT cross sutures because the dura is adherent to the skull at suture lines.

12. Triage: When to Refer
ScenarioUrgencyAction
Any suspected EDHEmergencyUrgent CT Head. Neurosurgery referral.
GCS Decline / Pupil ChangesEmergencyResuscitate. Transfer to Neurosurgical centre.
Small EDH, GCS 15, StableUrgentNeurosurgery opinion. Admit. Observe. Repeat CT.

14. Patient/Layperson Explanation

What is an Extradural Haemorrhage?

An extradural haemorrhage is bleeding between the skull and the brain's covering (dura) after a head injury. It is usually caused by damage to a blood vessel in the temple area.

Why is it dangerous?

Blood builds up quickly and presses on the brain. This can cause unconsciousness, brain damage, and death if not treated urgently.

What is the "Lucid Interval"?

Someone may be knocked out briefly, wake up and seem fine, then suddenly get much worse as the bleeding expands. This is a warning sign – seek help immediately if this occurs.

How is it treated?

  • Emergency surgery to remove the blood and stop the bleeding.

Key Counselling Points (Post-Operative)

  1. Follow-Up: "You will need monitoring and follow-up imaging."
  2. Warning Signs: "Report any new headaches, confusion, or weakness."
  3. Recovery: "With prompt treatment, most people make a full recovery."

15. Quality Markers: Audit Standards
StandardTarget
CT Head within 1 hour of presentation for GCS <15100%
Neurosurgery referral within 1 hour of CT diagnosis100%
Time to surgery <4 hours for surgical EDH>0%

16. Historical Context
  • William Macewen (1879): Pioneer of surgical evacuation for intracranial haematomas.
  • Harvey Cushing: Advanced understanding of raised ICP and herniation syndromes.

17. References
  1. NICE NG232. Head Injury: Assessment and Early Management. nice.org.uk
  2. Bullock MR, et al. Surgical Management of Traumatic Brain Injury. Neurosurgery. 2006.

Last Reviewed: 2025-12-24 | MedVellum Editorial Team


Medical Disclaimer: MedVellum content is for educational purposes and clinical reference. Head injury is a medical emergency – seek immediate medical attention.

Last updated: 2025-12-24

At a Glance

EvidenceHigh
Last Updated2025-12-24
Emergency Protocol

Red Flags

  • Lucid Interval ("Talk and Die")
  • Fixed Dilated Pupil (Uncal Herniation)
  • Cushing's Triad (Hypertension, Bradycardia, Irregular Respiration)
  • Rapid GCS Decline

Clinical Pearls

  • **"Lemon Shape = Extradural"**: Biconvex. Subdural is crescent-shaped.
  • **"Lucid Interval = High Index of Suspicion"**: Patient who was knocked out, wakes up, then deteriorates rapidly.
  • **"Blown Pupil = Ipsilateral to Lesion"**: CN III compressed against tentorium.
  • **"Does NOT Cross Sutures"**: Dura is adherent at suture lines.
  • Rapid accumulation of blood. |

Guidelines

  • NICE Guidelines
  • BTS Guidelines
  • RCUK Guidelines