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Eating Disorders

High EvidenceUpdated: 2025-12-24

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Red Flags

  • BMI <15 (Or Rapid Weight Loss)
  • Cardiac Arrhythmias (Bradycardia, QTc Prolongation)
  • Electrolyte Disturbance (Hypokalaemia)
  • Syncope
  • Suicidal Ideation
  • Refeeding Syndrome Risk
Overview

Eating Disorders

1. Topic Overview (Clinical Overview)

Summary

Eating disorders are serious mental health conditions characterised by abnormal eating behaviours, distorted body image, and significant physical and psychological consequences. The main types are Anorexia Nervosa (AN) – Restriction, Low BMI, Fear of weight gain; Bulimia Nervosa (BN) – Binge-Purge cycles; and Binge Eating Disorder (BED) – Bingeing without compensatory behaviours. Other categories include OSFED (Other Specified Feeding or Eating Disorder) and ARFID (Avoidant/Restrictive Food Intake Disorder). Anorexia Nervosa has the highest mortality rate of any psychiatric disorder (~10%). Medical complications include electrolyte disturbances (Hypokalaemia, Hyponatraemia), cardiac arrhythmias, osteoporosis, and Refeeding Syndrome (Phosphate depletion during nutritional rehabilitation – Can be fatal). Management involves a multidisciplinary approach: Psychological therapies (CBT-ED, MANTRA, SSCM), nutritional rehabilitation, and monitoring for medical complications. NICE NG69 provides comprehensive guidance.

Key Facts

  • Anorexia Nervosa (AN): Restriction, Low BMI (<17.5), Intense fear of weight gain, Distorted body image.
  • Bulimia Nervosa (BN): Recurrent binge eating + Compensatory behaviours (Purging, Laxatives, Exercise). Normal/Overweight BMI.
  • Binge Eating Disorder (BED): Bingeing without compensatory behaviours. Often obese.
  • Mortality: AN = Highest mortality of psychiatric disorders (~10%).
  • Refeeding Syndrome: Risk in severely malnourished. Monitor Phosphate.
  • Treatment: CBT-ED (BN, BED). MANTRA, CBT-ED, SSCM (AN). Fluoxetine (BN).

Clinical Pearls

"Anorexia Kills": Highest mortality of any psychiatric disorder. Physical monitoring is essential.

"Hypokalaemia in a Young Woman = Consider Bulimia": Purging (Vomiting, Laxatives) causes electrolyte disturbance.

"Refeeding Syndrome – Check Phosphate": When refeeding, phosphate drops rapidly. Can cause cardiac arrest.

"BMI Alone Doesn't Tell the Story": Rate of weight loss, medical complications, and psychological state are equally important.

Why This Matters Clinically

Eating disorders are common, serious, and often hidden. Early recognition and appropriate referral saves lives.


2. Epidemiology

Incidence

DisorderPrevalenceSex Ratio
Anorexia Nervosa~0.3-1% (Lifetime).F:M = 10:1 (Increasing in males).
Bulimia Nervosa~1-3% (Lifetime).F:M = 10:1.
Binge Eating Disorder~2-3% (Lifetime). Most common ED.F:M = 3:2 (More balanced).
  • Age of Onset: Often adolescence/early adulthood. Peak 14-19 years.
  • Increasing in: Males, Older adults, Ethnic minorities (Previously under-recognised).

Risk Factors

FactorNotes
Female Sex
AdolescencePubertal changes.
DietingCommon precursor.
Family HistoryGenetic component.
Personality TraitsPerfectionism, Obsessionality, Low self-esteem.
Trauma / AbuseChildhood sexual abuse (Bulimia).
Sports / OccupationsBallet, Gymnastics, Modelling.
Social/Cultural PressureThin ideal.
Comorbid Anxiety / Depression

3. Classification (ICD-11 / DSM-5)

Anorexia Nervosa (AN)

FeatureDescription
Restriction of Energy IntakeLeads to significantly low body weight.
Low Body WeightBMI <18.5 (Mild), <17 (Moderate), <16 (Severe), <15 (Extreme).
Intense Fear of Weight GainOr persistent behaviour preventing weight gain.
Disturbance in Body PerceptionDistorted body image. Undue influence of weight on self-evaluation. Lack of recognition of seriousness.
SubtypesRestricting Type vs Binge-Eating/Purging Type.

Bulimia Nervosa (BN)

FeatureDescription
Recurrent Binge EatingLarge amount of food in a short time. Sense of loss of control.
Recurrent Compensatory BehavioursVomiting, Laxatives, Diuretics, Fasting, Excessive Exercise.
FrequencyAt least once/week for 3 months (DSM-5).
Self-EvaluationUnduly influenced by body shape/weight.
BMIUsually normal or overweight.

Binge Eating Disorder (BED)

FeatureDescription
Recurrent Binge EatingLarge amount. Loss of control.
Associated FeaturesEating rapidly. Eating until uncomfortably full. Eating alone (Embarrassment). Disgust/Guilt after.
No Compensatory BehavioursDistinguishes from Bulimia.
FrequencyAt least once/week for 3 months.
BMIOften overweight/obese.

Other Specified Feeding or Eating Disorder (OSFED)

  • Does not meet full criteria for AN, BN, or BED but clinically significant.
  • E.g., Atypical AN (Normal weight AN), Subthreshold BN/BED.

Avoidant/Restrictive Food Intake Disorder (ARFID)

  • Avoidance/Restriction of food intake.
  • NOT due to body image concerns.
  • Leads to nutritional deficiency, Weight loss, Psychosocial impairment.
  • E.g., Sensory sensitivity, Fear of choking.

4. Clinical Presentation

Symptoms (By Disorder)

SymptomANBNBED
Restriction++++-
Low BMI+++--
Bingeing+ (Subtype)++++++
Purging (Vomiting, Laxatives)+ (Subtype)+++-
Excessive Exercise++++-
Fear of Weight Gain++++++-
Body Image Disturbance++++++++

Physical Signs

SignUnderlying Cause
Low BMI / CachexiaAN.
Lanugo HairDowny hair on face/body (AN).
Russell's SignCalluses on knuckles from self-induced vomiting (BN).
Parotid Swelling / "Chipmunk Cheeks"Purging (BN).
Dental ErosionGastric acid from vomiting (BN).
BradycardiaAN. <60 bpm. Concerning if <50.
HypotensionAN.
HypothermiaAN.
OedemaHypoalbuminaemia (AN). Refeeding.
Muscle WastingAN.

Psychological Features


Preoccupation with food/weight/shape.
Common presentation.
Social withdrawal.
Common presentation.
Rituals around eating.
Common presentation.
Depression, Anxiety.
Common presentation.
Poor insight (Especially AN).
Common presentation.
5. Complications

Medical Complications

SystemComplication
CardiovascularBradycardia. Hypotension. Arrhythmias (QTc prolongation). Sudden cardiac death.
ElectrolytesHypokalaemia (Purging). Hyponatraemia. Hypophosphataemia (Refeeding).
GIConstipation. Delayed gastric emptying. Pancreatitis (Refeeding).
EndocrineAmenorrhoea. Hypothyroidism (Sick euthyroid). Hypercortisolism.
BoneOsteopenia. Osteoporosis. Fractures.
HaematologicalAnaemia. Leucopenia. Thrombocytopenia.
RenalAKI. Chronic kidney disease (Laxative abuse).
NeurologicalCerebral atrophy (Reversible). Seizures.
DentalErosion (BN). Caries.
DermatologicalDry skin. Lanugo. Hair loss.

Refeeding Syndrome

FeatureNotes
DefinitionShift from catabolic to anabolic state causes rapid intracellular electrolyte shifts.
Key ElectrolyteHypophosphataemia. Also Hypokalaemia, Hypomagnesaemia.
Risk FactorsBMI <16, Little/No intake for >0 days, Low baseline Phosphate/K+/Mg++.
ComplicationsCardiac arrhythmias. Heart failure. Respiratory failure. Seizures. Death.
PreventionStart feeding slowly ("Start low, Go slow"). Monitor electrolytes. Prophylactic Thiamine, Phosphate, Potassium.

6. Investigations

Physical Assessment

TestPurpose
Weight, Height, BMIBaseline. Trend.
Orthostatic Vital SignsPostural hypotension.
Heart RateBradycardia <60.
TemperatureHypothermia.

Blood Tests

TestAbnormality
FBCAnaemia. Leucopenia. Thrombocytopenia.
U&EHypokalaemia (Purging). Hyponatraemia. AKI.
Phosphate, Magnesium, CalciumBaseline for refeeding.
LFTsElevated in starvation.
GlucoseHypoglycaemia.
TFTsSick euthyroid (Low T3).
Bone Profile / Vitamin D

ECG

  • Bradycardia.
  • QTc Prolongation (Risk of Torsades – Hypokalaemia).
  • ST/T changes.

DEXA

  • Bone density if prolonged amenorrhoea or low weight.

7. Management

Principles

  1. Multidisciplinary Team (Psychiatry, Dietitian, Physician, Nursing).
  2. Psychological Therapy (Core treatment).
  3. Nutritional Rehabilitation (Weight restoration in AN).
  4. Medical Monitoring (Bloods, ECG, Refeeding syndrome prevention).
  5. Treat Comorbidities (Depression, Anxiety).
  6. Medication (Adjunctive, Not first-line for AN).

Psychological Therapies (Per NICE NG69)

DisorderTherapyNotes
Anorexia Nervosa (Adults)MANTRA (Maudsley Model of AN Treatment for Adults). CBT-ED. SSCM (Specialist Supportive Clinical Management).Family therapy for adolescents.
Bulimia NervosaCBT-ED (First-line). Guided self-help.Fluoxetine 60mg (Adjunct).
Binge Eating DisorderCBT-ED (First-line). Guided self-help.Topiramate (Off-label, Limited). Lisdexamfetamine (USA).

Nutritional Rehabilitation (AN)

ApproachNotes
OutpatientMild AN. Medically stable.
Day PatientModerate. Structured meals.
Inpatient (Specialist Unit)Severe AN. BMI <15 or high risk. Medical instability. Failed outpatient.
Refeeding ProtocolStart low (e.g., 1200 kcal/day) and increase slowly. Monitor bloods. Thiamine/Phosphate supplementation.

Medications

DrugIndicationNotes
Fluoxetine 60mg ODBulimia Nervosa.Reduces binge-purge frequency. Not for AN.
LisdexamfetamineBinge Eating Disorder (USA).Not routinely UK.
OlanzapineSevere AN (refractory).May reduce weight preoccupation (Limited evidence).
SSRIsComorbid Depression/Anxiety.Not effective for core AN symptoms.

Admission Criteria (MARSIPAN – High Risk)

IndicatorNotes
BMI <13 (or Rapid decline)High risk.
Heart Rate <40 bpm
Systolic BP <90 mmHg
Postural HypotensionPulse rise >20, SBP drop >0.
Significant Electrolyte Disturbance
Temperature <35.5°C
QTc Prolongation >50ms
Hypoglycaemia
Acute Suicidal Risk

8. Prognosis & Outcomes
DisorderPrognosis
Anorexia Nervosa~50% Full recovery. ~30% Partial recovery. ~20% Chronic/Deceased. Mortality ~10% (Highest of any psychiatric disorder).
Bulimia Nervosa~50-70% Recovery with treatment.
Binge Eating DisorderGenerally good with treatment.

Mortality Causes (AN)

  1. Sudden Cardiac Death (Arrhythmias).
  2. Suicide.
  3. Infection.

9. Evidence & Guidelines

Key Guidelines

GuidelineOrganisationNotes
NICE NG69NICEEating Disorders: Recognition and Treatment.
MARSIPAN (Medical Emergencies in AN)RCPsych / RCPRisk assessment. Admission criteria.
Junior MARSIPANRCPsychFor under-18s.

10. Exam Scenarios

Scenario 1:

  • Stem: A 17-year-old girl presents with 6 months of weight loss, BMI 15.5, and fear of weight gain. She restricts her food intake. What is the diagnosis and first-line treatment?
  • Answer: Anorexia Nervosa (Restricting Type). First-line treatment: Family-based treatment (FBT) for adolescents. (Adults: MANTRA, CBT-ED, or SSCM).

Scenario 2:

  • Stem: A young woman with Bulimia Nervosa is found to have Hypokalaemia and QTc prolongation. What is the cause?
  • Answer: Electrolyte disturbance from Purging (Vomiting/Laxatives). Risk of cardiac arrhythmias.

Scenario 3:

  • Stem: What is the key electrolyte to monitor when refeeding a malnourished patient?
  • Answer: Phosphate. Refeeding syndrome causes severe Hypophosphataemia.

11. Triage: When to Refer
ScenarioUrgencyAction
Suspected Eating DisorderUrgentGP + Eating Disorder Service referral.
BMI <15 or Rapid Weight LossUrgentSpecialist Eating Disorder Service or Medical assessment.
Medical Instability (Bradycardia, Hypokalaemia, QTc prolongation)EmergencyAdmit (Medical +/- Psychiatric).
Suicidal IdeationEmergencyPsychiatric assessment.

12. Patient/Layperson Explanation

What are Eating Disorders?

Eating disorders are serious mental health conditions where people have an unhealthy relationship with food and their body. They include:

  • Anorexia: Extreme restriction of food. Very low weight.
  • Bulimia: Binge eating followed by purging (vomiting, laxatives).
  • Binge Eating Disorder: Eating large amounts without purging.

Why are they serious?

Eating disorders can cause serious health problems: Heart problems, Weak bones, Kidney damage, and can be fatal. Anorexia has the highest death rate of any mental illness.

How are they treated?

  • Psychological therapy: Talking therapies like CBT.
  • Nutritional support: Helping to restore healthy eating.
  • Medical monitoring: Checking heart, blood tests.
  • Sometimes medication: Especially for Bulimia.

Key Counselling Points

  1. Recovery is Possible: "With the right treatment, many people make a full recovery."
  2. Seek Help Early: "The sooner treatment starts, the better the outcome."
  3. Support is Available: "Organisations like BEAT (UK) offer help for patients and families."

14. Quality Markers: Audit Standards
StandardTarget
Physical assessment (Weight, HR, BP, Bloods) at first presentation100%
ECG if low BMI or electrolyte disturbance100%
Specialist Eating Disorder Service referral>5%
Refeeding protocol followed for high-risk patients100%

15. Historical Context
  • Sir William Gull (1868): First described Anorexia Nervosa ("Apepsia Hysterica").
  • Gerald Russell (1979): Described Bulimia Nervosa as a distinct entity.
  • Binge Eating Disorder: Added to DSM-5 (2013).

16. References
  1. NICE NG69. Eating Disorders: Recognition and Treatment. 2017. nice.org.uk
  2. MARSIPAN. Management of Really Sick Patients with Anorexia Nervosa. RCPsych. rcpsych.ac.uk

Last Reviewed: 2025-12-24 | MedVellum Editorial Team


Medical Disclaimer: MedVellum content is for educational purposes and clinical reference. If you or someone you know is struggling with an eating disorder, please seek help.

Last updated: 2025-12-24

At a Glance

EvidenceHigh
Last Updated2025-12-24

Red Flags

  • BMI &lt;15 (Or Rapid Weight Loss)
  • Cardiac Arrhythmias (Bradycardia, QTc Prolongation)
  • Electrolyte Disturbance (Hypokalaemia)
  • Syncope
  • Suicidal Ideation
  • Refeeding Syndrome Risk

Clinical Pearls

  • **"Anorexia Kills"**: Highest mortality of any psychiatric disorder. Physical monitoring is essential.
  • **"Hypokalaemia in a Young Woman = Consider Bulimia"**: Purging (Vomiting, Laxatives) causes electrolyte disturbance.
  • **"Refeeding Syndrome – Check Phosphate"**: When refeeding, phosphate drops rapidly. Can cause cardiac arrest.
  • **"BMI Alone Doesn't Tell the Story"**: Rate of weight loss, medical complications, and psychological state are equally important.
  • **Medical Disclaimer**: MedVellum content is for educational purposes and clinical reference. If you or someone you know is struggling with an eating disorder, please seek help.

Guidelines

  • NICE Guidelines
  • BTS Guidelines
  • RCUK Guidelines