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Ophthalmology
General Practice
Emergency Medicine

Viral Conjunctivitis

High EvidenceUpdated: 2025-12-24

On This Page

Red Flags

  • Severe Pain / Photophobia (Consider Keratitis)
  • Corneal Involvement (Dendritic Ulcer = HSV)
  • Contact Lens Wearer (Pseudomonas Keratitis Risk)
  • Unilateral Severe Eye (Consider HSV, Other Causes)
  • Visual Loss
Overview

Viral Conjunctivitis

1. Topic Overview (Clinical Overview)

Summary

Viral Conjunctivitis is an acute inflammation of the conjunctiva caused by a viral infection, most commonly Adenovirus. It is highly contagious and typically presents with a watery (serous) discharge, conjunctival injection (red eye), and gritty discomfort. It often starts unilaterally and spreads to the other eye within days. Patients commonly have a history of recent Upper Respiratory Tract Infection (URTI) or contact with someone with pink eye. The condition is self-limiting, usually resolving within 2-3 weeks. Management is supportive (lubricants, hygiene, no antibiotics). It is critical to exclude Herpes Simplex Virus (HSV) keratitis (Dendritic Ulcer) in patients with vesicular rash, recurrent episodes, or unilateral pain/photophobia.

Key Facts

  • Most Common Cause: Adenovirus.
  • Transmission: Highly contagious. Direct contact, Fomites.
  • Presentation: Watery discharge, Red eye, Gritty sensation, Pre-auricular lymphadenopathy.
  • Associations: Recent URTI, Contact with infected person, Outbreaks (Schools, Pools).
  • Course: Worsens over 3-5 days, resolves in 2-3 weeks.
  • Treatment: Supportive (Lubricants, Hygiene). NO Antibiotics.
  • Red Flag: Severe pain/photophobia -> Consider HSV Keratitis.

Clinical Pearls

"Watery = Viral, Purulent = Bacterial": Viral conjunctivitis produces a watery (serous) discharge. Thick purulent (yellow-green) discharge suggests bacterial infection.

"Pre-Auricular Lymph Nodes": Palpable pre-auricular lymph nodes are characteristic of viral (especially adenoviral) conjunctivitis.

"ALWAYS Exclude HSV": If there is vesicular rash, severe photophobia, recurrent unilateral eye disease, or dendritic ulcer on slit lamp -> Suspect HSV. Never give steroids without excluding HSV.

"No Antibiotics": Viral conjunctivitis is self-limiting. Antibiotic drops do not help and contribute to resistance.

Why This Matters Clinically

Viral conjunctivitis is extremely common and highly contagious. Recognising it avoids unnecessary antibiotic prescriptions. However, missing HSV keratitis can lead to blindness.


2. Epidemiology

Incidence

  • Very Common: Accounts for ~80% of acute conjunctivitis.
  • Age: All ages. Common in children.
  • Outbreaks: Schools, Swimming pools, Families.
  • Seasonal: Often autumn/winter (coincides with URTI season).

Causative Organisms

OrganismNotes
Adenovirus (Most Common)Serotypes 3, 4, 7 (PCF). 8, 19, 37 (EKC – Epidemic Keratoconjunctivitis).
Herpes Simplex Virus (HSV)Vesicular lid lesions. Dendritic ulcer. Recurrent.
Varicella Zoster Virus (VZV)Herpes Zoster Ophthalmicus. Dermatomal rash.
Enterovirus (Coxsackie A24, Enterovirus 70)Acute Haemorrhagic Conjunctivitis.
Molluscum ContagiosumLid lesions. Follicular conjunctivitis.
MeaslesKoplik spots. Keratitis.

3. Pathophysiology

Mechanism

  1. Virus Entry: Via direct contact with infected secretions or fomites.
  2. Infection of Conjunctival Epithelium: Viral replication.
  3. Inflammatory Response: Lymphocyte infiltration. Follicles form on conjunctiva.
  4. Recruitment of Pre-Auricular Lymph Nodes: Lymphatic drainage.
  5. Corneal Involvement (Some Serotypes): Subepithelial infiltrates (Adenovirus EKC) – Can persist for months.

Why Pre-Auricular Lymph Nodes?

  • The conjunctiva drains to the pre-auricular lymph nodes.
  • In viral conjunctivitis (especially Adenovirus), there is a robust lymphocytic response.

4. Clinical Presentation

Symptoms

SymptomNotes
Watery (Serous) DischargeKey differentiator from bacterial (purulent).
Red Eye (Conjunctival Injection)Diffuse. Often bilateral (Sequential).
Gritty / Foreign Body SensationUncomfortable but NOT severe pain.
Eyelid SwellingMild to moderate.
Burning / ItchingMild.
Mattering of LidsCrusty lids in morning (Less than bacterial).
Recent URTIPreceding or concurrent cold/sore throat.

Signs

SignNotes
Conjunctival FolliclesRaised, pale bumps (Lymphoid tissue) on inferior tarsal conjunctiva.
Pre-Auricular LymphadenopathyPalpable. Highly suggestive.
Eyelid Oedema
Bilateral Involvement (Sequential)May start unilateral, spreads.
Subepithelial Infiltrates (EKC)Corneal haze. Photosensitivity. Weeks-months.

Course


Onset
Often unilateral.
Peak
Worsens over 3-5 days.
Spread
To other eye within days.
Resolution
2-3 weeks. Subepithelial infiltrates may persist longer (EKC).
5. Clinical Examination

Systematic Examination

StepDetail
AcuityCheck visual acuity. Should be near-normal (Blurred by discharge).
EyelidsLid swelling. Check for vesicles (HSV/HZO).
ConjunctivaInjection (Diffuse). Follicles (Inferior fornix).
Pre-Auricular NodesPalpate. Suggestive of viral.
CorneaFluorescein staining. Exclude Dendritic Ulcer (HSV).
PupilsShould be normal.

Fluorescein Staining (Critical)

FindingInterpretation
NormalNo epithelial defect.
Dendritic UlcerBranching pattern. HSV KERATITIS. Urgent.
Punctate ErosionsNon-specific. Seen in viral.
Subepithelial InfiltratesEKC (Adenovirus).

6. Differential Diagnosis
ConditionKey Features
Bacterial ConjunctivitisPurulent (Mucopurulent) discharge. Eyelids stuck together. No lymph nodes.
Allergic ConjunctivitisWatery + Itchy. Bilateral. Seasonal. Cobblestone papillae.
HSV KeratitisUnilateral. Vesicular lid lesions. Dendritic ulcer. Photophobia. Pain.
Chlamydial ConjunctivitisChronic. Follicles. Sexually active. Bilateral. Discharge.
Gonococcal ConjunctivitisHyperacute. Copious purulent discharge. Emergency (Corneal perforation risk).
Acute Angle-Closure GlaucomaSevere pain. Halos. Mid-dilated pupil. Raised IOP.
Anterior Uveitis (Iritis)Pain. Photophobia. Ciliary flush. Miosis.
KeratitisPain. Photophobia. Corneal staining.
Episcleritis / ScleritisSectoral redness (Episcleritis). Deep boring pain (Scleritis).

7. Investigations

Clinical Diagnosis

  • Viral conjunctivitis is a clinical diagnosis.
  • Investigations are rarely needed in typical cases.

When to Investigate

ScenarioInvestigation
Suspected HSV KeratitisSlit lamp (Dendritic Ulcer). Viral swab/PCR.
Severe/Atypical CaseConjunctival swab (Viral PCR).
Outbreak InvestigationAdenovirus PCR.
Contact Lens Wearer with PainUrgent Ophthalmology (Exclude Pseudomonas Keratitis).

8. Management

Principles

  1. Supportive (Self-limiting).
  2. Hygiene (Prevent spread).
  3. Exclude HSV / Serious Causes.
  4. NO Antibiotics.

Supportive Treatment

InterventionDetail
Lubricating Eye DropsArtificial tears for comfort (e.g., Hypromellose).
Cold CompressesFor lid swelling.
AnalgesiaParacetamol for discomfort.

Hygiene Measures (Critical)

MeasureRationale
Hand HygieneWash hands frequently. Do not touch eyes.
Avoid SharingTowels, Pillows, Eye drops, Makeup.
Dispose of TissuesImmediately after use.
Stay Off Work/SchoolHighly contagious. 2 weeks.
No Contact LensesUntil fully resolved.

What NOT to Do

Do NotReason
AntibioticsViral. Ineffective. Resistance.
SteroidsCan worsen HSV. Do not give unless HSV excluded and Ophthalmology advice.
Share Eye DropsCross-contamination.

When to Refer to Ophthalmology

ScenarioAction
Pain / PhotophobiaUrgent. Exclude Keratitis.
Dendritic Ulcer on FluoresceinUrgent. HSV Keratitis.
Contact Lens WearerUrgent. Exclude Pseudomonas.
Visual LossUrgent.
Persistent > Weeks / WorseningRoutine.

9. Complications
ComplicationNotes
Subepithelial Infiltrates (EKC)Corneal haze. Photosensitivity. Persists weeks-months. May need steroid drops (Specialist).
Secondary Bacterial InfectionRare.
Spread to ContactsOutbreaks in families, schools.
Pseudomembrane/MembraneSevere cases (Adenovirus). May cause scarring.

10. Prognosis & Outcomes
  • Self-Limiting: Resolves in 2-3 weeks.
  • Vision: Usually preserved. Minor transient blur (discharge).
  • Subepithelial Infiltrates (EKC): May cause glare/blur for months. Eventually resolves.

11. Evidence & Guidelines

Key Guidelines

GuidelineOrganisationNotes
NICE CKS: Conjunctivitis – InfectiveNICEUK Primary Care guidance.
College of OptometristsUKRed eye pathways.

12. Exam Scenarios

Scenario 1:

  • Stem: A 25-year-old presents with a red, watery eye for 3 days. He had a cold last week. Pre-auricular lymph node is palpable. What is the most likely diagnosis?
  • Answer: Viral Conjunctivitis (Probably Adenoviral).

Scenario 2:

  • Stem: What is the key clinical feature differentiating viral from bacterial conjunctivitis?
  • Answer: Discharge: Watery = Viral. Purulent = Bacterial. Pre-auricular lymph nodes = Viral.

Scenario 3:

  • Stem: A patient with unilateral red eye has severe photophobia and vesicular lesions on the eyelid. What must you exclude?
  • Answer: HSV Keratitis. Perform fluorescein staining – Look for Dendritic Ulcer.

14. Triage: When to Refer
ScenarioUrgencyAction
Typical viral conjunctivitisRoutineGP/Self-care. Supportive. Hygiene.
Pain / PhotophobiaUrgentOphthalmology. Exclude Keratitis.
Contact Lens Wearer with Red EyeUrgentOphthalmology. Exclude Pseudomonas.
Visual LossUrgentOphthalmology.
Vesicular Rash on LidUrgentOphthalmology. Exclude HSV/HZO.
Not Improving at 3 WeeksRoutineOphthalmology.

15. Patient/Layperson Explanation

What is Viral Conjunctivitis (Pink Eye)?

Viral conjunctivitis is an infection of the thin layer covering the white of your eye. It's usually caused by the same viruses that cause colds. It makes your eye red, watery, and uncomfortable.

Is it contagious?

Yes, very. It spreads easily through touching your eyes and then touching objects or other people. Wash your hands often and don't share towels.

How is it treated?

  • It gets better on its own in 2-3 weeks.
  • Use lubricating eye drops for comfort.
  • No antibiotics (They don't work for viruses).
  • Keep hands clean. Stay off work/school if you can.

Key Counselling Points

  1. No Antibiotics Needed: "This is caused by a virus, so antibiotics won't help."
  2. Highly Contagious: "Wash your hands frequently. Don't share towels."
  3. Self-Limiting: "It will get better on its own in 2-3 weeks."
  4. Red Flags: "Come back if you have severe pain, sensitivity to light, or blurred vision."

16. Quality Markers: Audit Standards
StandardTarget
Antibiotic prescribing avoided in viral conjunctivitis>0%
Fluorescein staining performed if pain/photophobia100%
Contact lens wearers referred urgently100%
Safety-netting advice documented100%

17. Historical Context
  • "Pink Eye": Common layperson term for any red eye, most often used for infectious conjunctivitis.
  • Adenovirus Discovery (1950s): Adenoviruses first isolated from adenoid tissue, hence the name.
  • Epidemic Keratoconjunctivitis (EKC): Recognised as a distinct, highly contagious form with corneal involvement.

18. References
  1. NICE CKS: Conjunctivitis – Infective. cks.nice.org.uk
  2. Rietveld RP, et al. Predicting bacterial cause in infectious conjunctivitis. BMJ. 2004. PMID: 15258006


Medical Disclaimer: MedVellum content is for educational purposes and clinical reference. If you have severe eye pain or vision problems, please seek urgent medical attention.

Last updated: 2025-12-24

At a Glance

EvidenceHigh
Last Updated2025-12-24

Red Flags

  • Severe Pain / Photophobia (Consider Keratitis)
  • Corneal Involvement (Dendritic Ulcer = HSV)
  • Contact Lens Wearer (Pseudomonas Keratitis Risk)
  • Unilateral Severe Eye (Consider HSV, Other Causes)
  • Visual Loss

Clinical Pearls

  • Consider HSV Keratitis.
  • **"Watery = Viral, Purulent = Bacterial"**: Viral conjunctivitis produces a watery (serous) discharge. Thick purulent (yellow-green) discharge suggests bacterial infection.
  • **"Pre-Auricular Lymph Nodes"**: Palpable pre-auricular lymph nodes are characteristic of viral (especially adenoviral) conjunctivitis.
  • **"ALWAYS Exclude HSV"**: If there is vesicular rash, severe photophobia, recurrent unilateral eye disease, or dendritic ulcer on slit lamp -
  • Suspect HSV. Never give steroids without excluding HSV.

Guidelines

  • NICE Guidelines
  • BTS Guidelines
  • RCUK Guidelines