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Allergic Rhinitis

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Overview

Allergic Rhinitis

Quick Reference

Critical Alerts

  • Allergic rhinitis is not an emergency but commonly presents to ED
  • Rule out other causes: Sinusitis, URI, foreign body
  • Intranasal corticosteroids are most effective: For persistent symptoms
  • Second-generation antihistamines are first-line: Less sedating
  • Watch for asthma comorbidity: 40% of allergic rhinitis patients have asthma
  • Refer to allergist for severe or refractory cases

Key Features

FeatureAllergic Rhinitis
Nasal congestionBilateral
RhinorrheaClear, watery
SneezingParoxysmal
PruritusNose, eyes, palate
Eye symptomsWatery, itchy (allergic conjunctivitis)
TriggersPollen, dust, pet dander

Emergency Treatments

InterventionDetails
Intranasal corticosteroidFluticasone, mometasone
Oral antihistamineCetirizine, loratadine, fexofenadine
Intranasal antihistamineAzelastine
DecongestantPseudoephedrine (short-term)
Allergen avoidanceKey preventive measure

Definition

Overview

Allergic rhinitis is IgE-mediated inflammation of the nasal mucosa in response to inhaled allergens. It is characterized by nasal congestion, rhinorrhea, sneezing, and pruritus. While not a medical emergency, patients may present to the ED seeking symptom relief or when symptoms overlap with other conditions (sinusitis, asthma exacerbation).

Classification

By Timing:

TypeFeatures
Seasonal (hay fever)Pollen (spring, fall)
PerennialYear-round (dust mites, pet dander, mold)

By Severity (ARIA Classification):

SeverityFeatures
Intermittent<4 days/week or <4 weeks
Persistent>4 days/week and > weeks
MildNo impairment of sleep, daily activities, work/school
Moderate-SevereImpairment of above

Epidemiology

  • Prevalence: 10-30% of adults
  • Most common allergic condition
  • Peak onset: Childhood to young adulthood
  • Strong association with asthma, eczema, allergic conjunctivitis

Etiology

Common Allergens:

TypeExamples
SeasonalTree pollen, grass, ragweed
PerennialDust mites, pet dander, mold, cockroach

Risk Factors:

FactorNotes
Family historyAtopy
EczemaAtopic march
AsthmaComorbid

Pathophysiology

Mechanism

  1. Allergen exposure: Inhalation
  2. IgE sensitization: First exposure → IgE production
  3. Re-exposure: Allergen cross-links IgE on mast cells
  4. Mast cell degranulation: Histamine, leukotrienes release
  5. Early-phase response: Sneezing, rhinorrhea, pruritus (minutes)
  6. Late-phase response: Nasal congestion (hours)

Clinical Presentation

Symptoms

SymptomDescription
Nasal congestionBilateral, variable
RhinorrheaClear, watery
SneezingParoxysmal
Nasal/Palatal pruritusItchy nose, roof of mouth
Post-nasal dripThroat clearing
Eye symptomsWatery, itchy, red (allergic conjunctivitis)
Seasonal patternWorsens with pollen exposure

History

Key Questions:

Physical Examination

FindingDescription
Allergic shinersDark circles under eyes
Allergic saluteNasal crease from rubbing
Pale, boggy turbinatesSwollen nasal mucosa
Clear rhinorrheaWatery discharge
Cobblestoning pharynxPost-nasal drip
Conjunctival injectionIf allergic conjunctivitis

Symptom timing (seasonal vs year-round)
Common presentation.
Triggers (pollen, pets, dust)
Common presentation.
Eye symptoms
Common presentation.
Prior diagnosis of allergies, asthma, eczema
Common presentation.
Family history of atopy
Common presentation.
Current medications
Common presentation.
Interference with sleep or daily activities
Common presentation.
Red Flags

Exclude Other Diagnoses

FindingConcernAction
Unilateral symptomsForeign body, polyp, tumorImaging
Purulent dischargeSinusitisTreat as indicated
FeverInfectionRule out sinusitis
EpistaxisCoagulopathy, traumaEvaluate
Wheezing, dyspneaAsthmaTreat asthma

Differential Diagnosis

Other Causes of Nasal Symptoms

DiagnosisFeatures
Viral URIFever, systemic symptoms, self-limited
Acute sinusitisPurulent discharge, facial pain
Non-allergic rhinitisNo allergen trigger, no IgE
Vasomotor rhinitisTriggered by temperature, odors
Rhinitis medicamentosaOveruse of decongestant sprays
Nasal polypsChronic congestion, anosmia
Foreign bodyUnilateral, foul discharge (children)

Diagnostic Approach

Clinical Diagnosis

  • Allergic rhinitis is a clinical diagnosis
  • Based on history and exam

Testing (Usually Outpatient)

TestIndication
Skin prick testingConfirm allergens
Serum-specific IgEAlternative to skin testing

Laboratory

  • Not routinely needed in ED

Treatment

Principles

  1. Allergen avoidance: Primary prevention
  2. Pharmacotherapy: Based on symptom severity
  3. Combination therapy for moderate-severe
  4. Immunotherapy for refractory: Outpatient

First-Line: Intranasal Corticosteroids

Most Effective for Persistent Symptoms:

AgentDose
Fluticasone1-2 sprays each nostril daily
Mometasone1-2 sprays each nostril daily
Budesonide1-2 sprays each nostril daily

Onset: 12 hours to full effect in 1-2 weeks

Second-Line: Oral Antihistamines

Second-Generation (Preferred—Less Sedating):

AgentDose
Cetirizine10 mg daily
Loratadine10 mg daily
Fexofenadine180 mg daily

First-Generation (More Sedating):

AgentDose
Diphenhydramine25-50 mg q6h
Chlorpheniramine4 mg q4-6h

Additional Therapies

Intranasal Antihistamine:

AgentDose
Azelastine1-2 sprays each nostril BID

Decongestants (Short-Term Only):

AgentDoseNotes
Pseudoephedrine60 mg q4-6hMax 3-5 days for topical
Oxymetazoline nasal2-3 sprays q12hAvoid > days (rebound)

Leukotriene Receptor Antagonist:

AgentDose
Montelukast10 mg daily

Eye Symptoms (Allergic Conjunctivitis):

AgentDose
Olopatadine1 drop each eye BID
Ketotifen1 drop each eye BID

Allergen Avoidance

AllergenMeasures
Dust mitesEncase mattress, wash bedding, reduce humidity
Pet danderRemove pets, HEPA filters
PollenClose windows, shower after outdoors
MoldFix leaks, reduce humidity

Disposition

Discharge Criteria

  • Symptoms controlled
  • Medications prescribed
  • Follow-up arranged

Admission Criteria

  • Not typically indicated for allergic rhinitis

Referral

IndicationReferral
Refractory symptomsAllergist
Need for immunotherapyAllergist
Comorbid asthmaPulmonology/Allergy

Patient Education

Condition Explanation

  • "You have allergies that cause inflammation in your nose."
  • "The best treatment is a steroid nasal spray, which works over a few days."
  • "Avoiding your triggers (pollen, dust, pets) can help."

Home Care

  • Use nasal spray daily for best effect
  • Take antihistamines as directed
  • Avoid known triggers
  • Shower and change clothes after outdoor activities (for pollen)
  • Use HEPA air filters

Warning Signs to Return

  • Symptoms not improving after 1-2 weeks
  • Facial pain, fever (sinusitis)
  • Wheezing or difficulty breathing
  • Any sign of severe allergic reaction

Special Populations

Pregnancy

  • Intranasal corticosteroids (budesonide) safe
  • Second-gen antihistamines generally safe (cetirizine, loratadine)
  • Avoid decongestants (pseudoephedrine) especially in first trimester

Children

  • Intranasal steroids safe
  • Second-gen antihistamines preferred
  • Rule out foreign body in unilateral symptoms

Elderly

  • Avoid first-gen antihistamines (sedation, anticholinergic effects)
  • Be cautious with decongestants (HTN, BPH)

Quality Metrics

Performance Indicators

MetricTargetRationale
Intranasal steroid prescribed for moderate-severe>0%Most effective
Second-gen antihistamine over first-gen>0%Less sedation
Decongestant limited to short course100%Avoid rebound

Documentation Requirements

  • Symptom pattern (seasonal vs perennial)
  • Trigger identification
  • Comorbid asthma
  • Treatment and follow-up

Key Clinical Pearls

Diagnostic Pearls

  • Itching = Allergy: Pruritus is key feature
  • Clear watery rhinorrhea: Vs purulent in sinusitis
  • Bilateral and seasonal: Classic pattern
  • Allergic shiners and salute: Physical exam clues
  • Rule out sinusitis if fever or purulent discharge
  • Unilateral symptoms warrant further workup

Treatment Pearls

  • Intranasal steroids are most effective: For persistent symptoms
  • Second-gen antihistamines are first-line: Less sedating
  • Decongestants for short-term only: Rebound congestion
  • Combination therapy for moderate-severe
  • Allergen avoidance is cornerstone: Prevention
  • Leukotriene antagonists useful in asthma comorbidity

Disposition Pearls

  • Allergic rhinitis rarely needs admission
  • Refer refractory cases to allergist: Immunotherapy
  • Screen for and treat comorbid asthma
  • Educate on long-term use of intranasal steroids

References
  1. Brozek JL, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines. J Allergy Clin Immunol. 2017;140(4):1099-1143.
  2. Wheatley LM, Togias A. Allergic rhinitis. N Engl J Med. 2015;372(5):456-463.
  3. Seidman MD, et al. Clinical practice guideline: Allergic rhinitis. Otolaryngol Head Neck Surg. 2015;152(1 Suppl):S1-S43.
  4. Wallace DV, et al. The diagnosis and management of rhinitis: An updated practice parameter. J Allergy Clin Immunol. 2008;122(2 Suppl):S1-S84.
  5. Dykewicz MS, et al. Treatment of seasonal allergic rhinitis: An evidence-based guideline. Ann Allergy Asthma Immunol. 2017;119(6):489-511.
  6. Greiner AN, et al. Allergic rhinitis. Lancet. 2011;378(9809):2112-2122.
  7. ARIA Guidelines. Allergic rhinitis and its impact on asthma. 2020.
  8. UpToDate. Pharmacotherapy of allergic rhinitis. 2024.

At a Glance

EvidenceStandard
Last UpdatedRecently

Guidelines

  • NICE Guidelines
  • BTS Guidelines
  • RCUK Guidelines