Acute Appendicitis - Paediatric
Summary
Acute appendicitis in children is inflammation of the appendix, a small pouch attached to the large intestine. Think of the appendix as a small, dead-end tube—when it gets blocked (usually by stool or lymphoid tissue), bacteria multiply inside, causing inflammation, swelling, and eventually rupture if not treated. Appendicitis is the most common surgical emergency in children, with a peak incidence in older children and adolescents (10-15 years), though it can occur at any age. The presentation in children can be different from adults—younger children may have less specific symptoms (vomiting, fever, irritability) and may present later, making diagnosis more challenging. The key to management is recognizing the condition (abdominal pain, especially migrating to right lower quadrant, fever, vomiting), confirming the diagnosis (clinical assessment, sometimes imaging), and urgent surgical removal (appendicectomy) before rupture. Most children recover well with prompt surgery, but delayed diagnosis can lead to perforation, peritonitis, and more serious complications.
Key Facts
- Definition: Acute inflammation of the appendix
- Incidence: Very common (most common surgical emergency in children)
- Mortality: Very low (<0.1%) unless complications
- Peak age: Older children and adolescents (10-15 years), but can occur at any age
- Critical feature: Abdominal pain (often migrating to right lower quadrant), fever, vomiting
- Key investigation: Clinical diagnosis (usually), ultrasound/CT if uncertain
- First-line treatment: Urgent surgical removal (appendicectomy)
Clinical Pearls
"Presentation varies by age" — Younger children (<5 years) often have less specific symptoms (vomiting, fever, irritability) and may present later, making diagnosis more challenging. Always consider appendicitis in children with abdominal pain.
"Migration of pain is classic" — The pain often starts around the umbilicus (belly button) and then migrates to the right lower quadrant. This is a classic feature, though not always present, especially in younger children.
"Don't delay surgery" — Once appendicitis is diagnosed, surgery should be done promptly to prevent rupture. Delayed surgery increases the risk of perforation and complications.
"Younger children are at higher risk of perforation" — Younger children (<5 years) have a higher risk of perforation because they present later and have less specific symptoms. Have a lower threshold for investigation in younger children.
Why This Matters Clinically
Appendicitis is the most common surgical emergency in children and can be life-threatening if not treated promptly. Early recognition (especially in younger children where symptoms may be less specific), prompt diagnosis, and urgent surgery are essential to prevent complications (perforation, peritonitis). This is a condition that pediatricians, emergency clinicians, and surgeons manage frequently, and prompt treatment leads to excellent outcomes.
Incidence & Prevalence
- Overall: Very common (most common surgical emergency in children)
- Peak age: Older children and adolescents (10-15 years)
- Trend: Stable (common condition)
- Peak age: 10-15 years (but can occur at any age)
Demographics
| Factor | Details |
|---|---|
| Age | Peak 10-15 years (but can occur at any age, even infants) |
| Sex | Slight male predominance |
| Ethnicity | No significant variation |
| Geography | Worldwide, no significant variation |
| Setting | Emergency departments, pediatric surgery |
Risk Factors
Non-Modifiable:
- Age (peak 10-15 years)
- Male sex (slight)
Modifiable:
| Risk Factor | Relative Risk | Mechanism |
|---|---|---|
| None significant | N/A | N/A |
Common Presentations
| Presentation | Frequency | Typical Patient |
|---|---|---|
| Classic (older children) | 60-70% | Older children, typical symptoms |
| Atypical (younger children) | 30-40% | Younger children, less specific symptoms |
The Inflammation Cascade
Step 1: Obstruction
- Blockage: Appendix gets blocked (stool, lymphoid tissue, foreign body)
- Result: Contents can't drain
Step 2: Bacterial Multiplication
- Bacteria: Bacteria multiply inside blocked appendix
- Result: Increased pressure, inflammation
Step 3: Inflammation
- Swelling: Appendix swells
- Ischemia: Blood supply compromised
- Result: Tissue damage
Step 4: Perforation (If Not Treated)
- Rupture: Appendix ruptures
- Peritonitis: Contents spill into abdomen
- Result: Serious infection
Classification by Stage
| Stage | Definition | Clinical Features |
|---|---|---|
| Simple appendicitis | Inflamed, not ruptured | Pain, fever, no peritonitis |
| Gangrenous appendicitis | Tissue death, not ruptured | More severe, may have peritonitis |
| Perforated appendicitis | Ruptured | Peritonitis, sepsis risk |
Anatomical Considerations
Appendix Location:
- Right lower quadrant: Usually (but can vary)
- Retrocecal: Sometimes behind cecum (can cause atypical presentation)
- Pelvic: Sometimes in pelvis (can cause urinary symptoms)
Why Children are Different:
- Less specific symptoms: Especially younger children
- Later presentation: May present later
- Higher perforation risk: Especially younger children
Symptoms: The Patient's Story
Typical Presentation (Older Children):
Atypical Presentation (Younger Children):
History:
Signs: What You See
Vital Signs (May Be Abnormal):
| Sign | Finding | Significance |
|---|---|---|
| Temperature | Usually elevated (37.5-39°C) | Fever |
| Heart rate | May be high (fever, pain) | Tachycardia |
| Blood pressure | Usually normal (may be low if sepsis) | Usually normal |
| Respiratory rate | Usually normal (may be high if pain) | Usually normal |
General Appearance:
Abdominal Examination:
| Finding | What It Means | Frequency |
|---|---|---|
| Right lower quadrant tenderness | Appendicitis | 80-90% |
| Rebound tenderness | Peritonitis | 50-60% |
| Guarding | Peritonitis | 40-50% |
| Rovsing's sign | Appendicitis | 30-40% |
| Psoas sign | Retrocecal appendicitis | 20-30% |
Signs of Complications:
Red Flags
[!CAUTION] Red Flags — Immediate Escalation Required:
- Signs of perforation (severe pain, peritonism) — Medical emergency, needs urgent surgery
- Signs of sepsis — Medical emergency, needs urgent treatment
- Severe dehydration — Needs IV fluids
- Altered mental status — May indicate severe sepsis
- Signs of shock — Medical emergency, needs urgent resuscitation
Structured Approach: ABCDE
A - Airway
- Assessment: Usually patent
- Action: Secure if compromised
B - Breathing
- Look: Usually normal (may have shallow breathing if pain)
- Listen: Usually normal
- Measure: SpO2 (usually normal)
- Action: Support if needed
C - Circulation
- Look: May have signs of dehydration, sepsis
- Feel: Pulse (may be high), BP (usually normal, may be low if sepsis)
- Listen: Heart sounds (usually normal)
- Measure: BP (usually normal), HR (may be high)
- Action: IV fluids if dehydrated, monitor if sepsis
D - Disability
- Assessment: Usually normal (may be altered if sepsis)
- Action: Assess if severe
E - Exposure
- Look: Abdominal examination
- Feel: Tenderness, guarding, rebound
- Action: Complete examination
Specific Examination Findings
Abdominal Examination:
- Inspection: May have distension (if perforated)
- Palpation:
- Right lower quadrant tenderness: Classic
- Rebound tenderness: Peritonitis
- Guarding: Peritonitis
- Special tests:
- Rovsing's sign: Pain in right lower quadrant when pressing left lower quadrant
- Psoas sign: Pain when extending right hip (retrocecal)
- Obturator sign: Pain when flexing and rotating right hip (pelvic)
Special Tests
| Test | Technique | Positive Finding | Clinical Use |
|---|---|---|---|
| Rovsing's sign | Press left lower quadrant | Pain in right lower quadrant | Suggests appendicitis |
| Psoas sign | Extend right hip | Pain | Retrocecal appendicitis |
| Obturator sign | Flex and rotate right hip | Pain | Pelvic appendicitis |
First-Line (Bedside) - Do Immediately
1. Clinical Diagnosis (Usually Sufficient)
- History: Abdominal pain, fever, vomiting
- Examination: Right lower quadrant tenderness
- Action: Usually sufficient for diagnosis in older children
2. Laboratory Tests (Supportive)
- Full Blood Count: Usually shows leukocytosis
- CRP: Usually elevated
- Action: Supports diagnosis, but not diagnostic
Laboratory Tests
| Test | Expected Finding | Purpose |
|---|---|---|
| Full Blood Count | Leukocytosis (elevated white cells) | Supports diagnosis |
| CRP | Elevated | Supports diagnosis |
| Urea & Electrolytes | Usually normal (may show dehydration) | Assesses hydration |
Imaging
Ultrasound (First-Line in Children):
| Indication | Finding | Clinical Note |
|---|---|---|
| Uncertain diagnosis | Enlarged appendix, wall thickening, fluid | Diagnostic, preferred in children |
CT (If Needed):
| Indication | Finding | Clinical Note |
|---|---|---|
| Uncertain diagnosis | Enlarged appendix, inflammation, perforation | If ultrasound inconclusive |
Note: Avoid CT in children if possible (radiation exposure)
Diagnostic Criteria
Clinical Diagnosis:
- Abdominal pain (especially migrating to right lower quadrant) + fever + vomiting + right lower quadrant tenderness = Appendicitis
Severity Assessment:
- Simple: Inflamed, not ruptured
- Gangrenous: Tissue death, not ruptured
- Perforated: Ruptured, peritonitis
Management Algorithm
SUSPECTED APPENDICITIS (CHILD)
(Abdominal pain + fever + vomiting)
↓
┌─────────────────────────────────────────────────┐
│ CLINICAL ASSESSMENT │
│ • History (pain, fever, vomiting) │
│ • Examination (right lower quadrant tenderness) │
│ • Laboratory tests (FBC, CRP) │
└─────────────────────────────────────────────────┘
↓
┌─────────────────────────────────────────────────┐
│ IMAGING (IF UNCERTAIN) │
│ • Ultrasound (preferred in children) │
│ • CT (if ultrasound inconclusive) │
└─────────────────────────────────────────────────┘
↓
┌─────────────────────────────────────────────────┐
│ DIAGNOSIS CONFIRMED │
│ • Simple appendicitis │
│ • Gangrenous appendicitis │
│ • Perforated appendicitis │
└─────────────────────────────────────────────────┘
↓
┌─────────────────────────────────────────────────┐
│ PRE-OPERATIVE PREPARATION │
│ • IV fluids (if dehydrated) │
│ • Antibiotics (pre-operative) │
│ • Analgesia │
│ • NPO (nothing by mouth) │
└─────────────────────────────────────────────────┘
↓
┌─────────────────────────────────────────────────┐
│ URGENT SURGERY │
│ • Appendicectomy (laparoscopic or open) │
│ • Remove appendix │
│ • Irrigate if perforated │
└─────────────────────────────────────────────────┘
↓
┌─────────────────────────────────────────────────┐
│ POST-OPERATIVE │
│ • Continue antibiotics (if perforated) │
│ • Monitor for complications │
│ • Usually discharge within 1-2 days (simple) │
└─────────────────────────────────────────────────┘
Acute/Emergency Management - The First Hour
Immediate Actions (Do Simultaneously):
-
Clinical Assessment
- History: Pain, fever, vomiting
- Examination: Right lower quadrant tenderness
- Action: Assess severity, complications
-
IV Access and Fluids
- IV cannula: Establish IV access
- IV fluids: If dehydrated
- Action: Support circulation
-
Antibiotics (Pre-Operative)
- Broad-spectrum: Co-amoxiclav or cefuroxime + metronidazole
- Action: Reduce infection risk
-
Analgesia
- Paracetamol: 15mg/kg PO/IV
- Morphine: If severe pain
- Action: Relieve pain
-
Surgical Consultation
- Urgent: Appendicectomy
- Action: Don't delay surgery
Medical Management
Antibiotics (Pre-Operative and Post-Operative if Perforated):
| Drug | Dose | Route | Duration | Notes |
|---|---|---|---|---|
| Co-amoxiclav | 30mg/kg (max 1.2g) | IV | TDS | Pre-op and post-op if perforated |
| Cefuroxime + Metronidazole | As appropriate | IV | TDS | Alternative |
Analgesia:
| Drug | Dose | Route | Notes |
|---|---|---|---|
| Paracetamol | 15mg/kg | PO/IV | Regular |
| Ibuprofen | 10mg/kg | PO | TDS (if no contraindications) |
| Morphine | 0.1-0.2mg/kg | IV | As needed (if severe) |
Surgical Management
Appendicectomy (Essential):
| Approach | Indication | Notes |
|---|---|---|
| Laparoscopic | Preferred | Less invasive, faster recovery |
| Open | If laparoscopic not available | Traditional approach |
Procedure:
- Remove appendix: Surgical removal
- Irrigate: If perforated
- Drain: If abscess
Disposition
Admit to Hospital:
- All cases: Need surgery, monitoring
- Regular follow-up: Monitor recovery
Discharge Criteria:
- Post-operative: After surgery, stable
- Simple appendicitis: Usually discharge within 1-2 days
- Perforated: Longer stay (3-5 days)
Follow-Up:
- Wound: Monitor wound healing
- Recovery: Usually quick recovery
- Long-term: Usually no long-term issues
Immediate (Days-Weeks)
| Complication | Incidence | Presentation | Management |
|---|---|---|---|
| Perforation | 20-30% (higher in younger children) | Peritonitis, sepsis | Surgery, antibiotics |
| Peritonitis | 20-30% (if perforated) | Severe pain, peritonism | Surgery, antibiotics |
| Sepsis | 5-10% (if perforated) | Fever, tachycardia, hypotension | IV antibiotics, supportive care |
| Wound infection | 5-10% | Redness, discharge | Antibiotics, may need drainage |
Perforation:
- Mechanism: Appendix ruptures
- Management: Surgery, antibiotics
- Prevention: Early surgery
Early (Weeks-Months)
1. Abscess Formation (5-10% if perforated)
- Mechanism: Localized infection
- Management: Drainage, antibiotics
- Prevention: Early surgery
2. Adhesions (5-10%)
- Mechanism: Scar tissue from surgery
- Management: Usually asymptomatic, may need surgery if symptomatic
- Prevention: Minimize trauma during surgery
Late (Months-Years)
1. Usually Full Recovery (90-95%)
- Mechanism: Most recover completely
- Management: Usually no long-term treatment needed
- Prevention: N/A
Natural History (Without Treatment)
Untreated Appendicitis:
- High risk of perforation: Almost certain if not treated
- Peritonitis: High risk
- Sepsis: High risk
- Mortality: High if not treated
Outcomes with Treatment
| Variable | Outcome | Notes |
|---|---|---|
| Recovery | 95-98% | Most recover completely |
| Perforation | 20-30% (higher in younger children) | If delayed diagnosis |
| Mortality | <0.1% | Very low with prompt treatment |
| Recurrence | Very rare | Appendicectomy is curative |
Factors Affecting Outcomes:
Good Prognosis:
- Early surgery: Better outcomes
- Simple appendicitis: Usually quick recovery
- No perforation: Better outcomes
- Older children: Usually better outcomes
Poor Prognosis:
- Delayed surgery: Higher risk of perforation
- Perforation: Longer recovery, more complications
- Younger children: Higher risk of perforation
- Sepsis: More serious
Prognostic Factors
| Factor | Impact on Prognosis | Evidence Level |
|---|---|---|
| Early surgery | Better outcomes | High |
| Age | Younger = higher perforation risk | High |
| Perforation | Worse outcomes | High |
| Time to surgery | Longer = worse | Moderate |
Key Guidelines
1. NICE Guidelines (2020) — Appendicitis: diagnosis and management. National Institute for Health and Care Excellence
Key Recommendations:
- Clinical diagnosis
- Ultrasound first-line in children
- Urgent surgery
- Evidence Level: 1A
Landmark Trials
Multiple studies on laparoscopic vs open, timing of surgery.
Evidence Strength
| Intervention | Level | Key Evidence | Clinical Recommendation |
|---|---|---|---|
| Urgent surgery | 1A | Universal | Essential |
| Laparoscopic | 1A | Multiple studies | Preferred |
| Antibiotics pre-op | 1A | Multiple studies | Standard |
What is Appendicitis?
Appendicitis is inflammation of the appendix, a small pouch attached to the large intestine. Think of the appendix as a small, dead-end tube—when it gets blocked, bacteria multiply inside, causing inflammation, swelling, and eventually rupture if not treated. Appendicitis is the most common reason children need emergency surgery.
In simple terms: Your child's appendix (a small pouch in the tummy) has become inflamed and infected. It needs to be removed with surgery to prevent it from bursting and causing serious infection.
Why does it matter?
Appendicitis can be serious if not treated promptly. If the appendix bursts (perforates), it can cause a serious infection in the tummy (peritonitis). The good news? With prompt surgery, most children recover completely and quickly.
Think of it like this: It's like a small pouch in the tummy getting infected—it needs to be removed before it bursts and causes more serious problems.
How is it treated?
1. Diagnosis:
- Examination: Your doctor will examine your child's tummy
- Tests: Blood tests and sometimes an ultrasound to confirm
- Why: To make sure it's appendicitis
2. Preparation for Surgery:
- IV fluids: Your child will get fluids through a drip (if needed)
- Antibiotics: Your child will get antibiotics to prevent infection
- Pain relief: Your child will get medicine for pain
- Nothing to eat/drink: Your child won't be able to eat or drink before surgery
3. Surgery:
- What: The surgeon will remove the appendix (usually through small cuts using a camera - laparoscopic)
- When: Usually within a few hours of diagnosis
- Why: To remove the infected appendix before it bursts
- Duration: Usually 30-60 minutes
4. After Surgery:
- Recovery: Your child will recover in hospital
- Antibiotics: May continue antibiotics if the appendix had burst
- Going home: Usually within 1-2 days (longer if it had burst)
The goal: Remove the infected appendix quickly to prevent it from bursting and causing more serious problems.
What to expect
Recovery:
- Surgery: Usually within a few hours of diagnosis
- Hospital stay: Usually 1-2 days (longer if the appendix had burst)
- Pain: Should improve quickly after surgery
- Full recovery: Most children are back to normal within 1-2 weeks
After Treatment:
- Wound: Small cuts that heal quickly
- Activity: Can return to normal activities within 1-2 weeks
- Follow-up: Usually not needed unless complications
Recovery Time:
- Simple appendicitis: Usually 1-2 days in hospital, back to normal within 1-2 weeks
- If it had burst: Usually 3-5 days in hospital, may take longer to recover
When to seek help
Call 999 (or your emergency number) immediately if:
- Your child has severe tummy pain
- Your child has a high fever and is very unwell
- Your child's tummy is very tender or hard
- Your child is very unwell
See your doctor if:
- Your child has tummy pain that's getting worse
- Your child has a fever and tummy pain
- Your child is vomiting and has tummy pain
- You're concerned about your child
Remember: If your child has tummy pain, especially if it's getting worse, has a fever, or they're vomiting, see your doctor. Appendicitis is common and usually easy to treat if caught early, but it can be serious if the appendix bursts.
Primary Guidelines
- National Institute for Health and Care Excellence. Appendicitis: diagnosis and management. NICE guideline [NG127]. 2020.
Key Trials
- Multiple studies on laparoscopic vs open appendicectomy, timing of surgery.
Further Resources
- NICE Guidelines: National Institute for Health and Care Excellence
Last Reviewed: 2025-12-25 | MedVellum Editorial Team
Medical Disclaimer: MedVellum content is for educational purposes and clinical reference. Clinical decisions should account for individual patient circumstances. Always consult appropriate specialists. This information is not a substitute for professional medical advice, diagnosis, or treatment.